Deakin University, Geelong Australia, School of Medicine, Australia.
Department for Management of Science and Technology Development, Ton Duc Thang University, Ho Chi Minh City, Vietnam; Faculty of Pharmacy, Ton Duc Thang University, Ho Chi Minh City, Vietnam.
Int J Pharm. 2020 Feb 15;575:118956. doi: 10.1016/j.ijpharm.2019.118956. Epub 2019 Dec 13.
Although fucoidan (FU) shows potential bioactivity against various diseases, it has also been demonstrated to be an excellent material for nanodelivery. FU can be utilized to prepare nanoparticles for drug loading or to stabilize nanoparticles and is often incorporated into nanostructure materials to extend or maximize its role in theranostics applications. This review discusses strategies involving FU and other material combinations used as nanostructures for biomedical applications with a focus on chitosan-FU mixtures for oral delivery and FU-based surface functionalization for targeting and theranostics. The ability of FU to form different nanostructures is also reviewed. Moreover, various types and mechanisms of combinations involving FU-based nanostructures are discussed. A discussion of the current outlook and future studies provides ideas for more efficacious methods for FU-based nanoparticles and could enable their utilization in clinical trials.
虽然褐藻糖胶 (FU) 对各种疾病显示出潜在的生物活性，但它也已被证明是一种出色的纳米递药材料。FU 可用于制备载药纳米颗粒，或稳定纳米颗粒，并且通常被纳入纳米结构材料中，以延长或最大限度发挥其在治疗应用中的作用。本综述讨论了涉及 FU 与其他材料组合用作生物医学应用的纳米结构的策略，重点是壳聚糖-FU 混合物用于口服递药以及基于 FU 的表面功能化用于靶向和治疗。还综述了 FU 形成不同纳米结构的能力。此外，还讨论了涉及基于 FU 的纳米结构的各种类型和机制的组合。对当前前景和未来研究的讨论为基于 FU 的纳米粒子提供了更有效的方法的思路，并可能使其能够在临床试验中得到应用。
