Department of Musculoskeletal Disorders, Faculty of Medicine and Surgery, University of Salerno, Via San Leonardo 1, 84131 Salerno, Italy.
Department of Medicine, Surgery and Dentistry, University of Salerno, Via S. Allende, 84081 Baronissi (SA), Italy.
Br Med Bull. 2019 Dec 11;132(1):53-80. doi: 10.1093/bmb/ldz034.
Given the limited regenerative capacity of injured articular cartilage, the absence of suitable therapeutic options has encouraged tissue-engineering approaches for its regeneration or replacement.
Published articles in any language identified in PubMed and Scopus electronic databases up to August 2019 about the in vitro and in vivo properties of cartilage engineered constructs. A total of 64 articles were included following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines.
Regenerated cartilage lacks the biomechanical and biological properties of native articular cartilage.
There are many different approaches about the development of the architecture and the composition of the scaffolds.
Novel tissue engineering strategies focus on the development of cartilaginous biomimetic materials able to repair cartilage lesions in association to cell, trophic factors and gene therapies.
A multi-layer design and a zonal organization of the constructs may lead to achieve cartilage regeneration.
鉴于受伤的关节软骨再生能力有限，缺乏合适的治疗选择促使人们采用组织工程方法来促进其再生或替代。
在 PubMed 和 Scopus 电子数据库中以任何语言发表的文章，检索时间截至 2019 年 8 月，内容为体外和体内软骨工程构建物的特性。根据系统评价和荟萃分析的首选报告项目指南，共纳入 64 篇文章。
再生软骨缺乏天然关节软骨的生物力学和生物学特性。
关于支架结构和组成的开发有许多不同的方法。
新型组织工程策略侧重于开发能够与细胞、营养因子和基因治疗相结合修复软骨损伤的类软骨仿生材料。
构建物的多层设计和区域组织可能会导致软骨再生。
