Vedig Alnis E, Gibbs John M, Rutten Albert J, Ilsley Anthony H
Department of Anaesthesia and Intensive Care, Flinders Medical Centre, Flinders University of South Australia, Adelaide, S.A.Australia.
Pain. 1988 Sep;34(3):253-259. doi: 10.1016/0304-3959(88)90120-0.
The effects on respiration and pain perception of giving 0.6 mg buprenorphine alone and of giving the same dose after the administration of pethidine intravenously to achieve a steady-state blood pethidine level (mean blood level 0.29-0.47 microgram/ml) were studied in 3 healthy male volunteers. Depression of ventilation occurred with both pethidine and buprenorphine, and the combination produced greater depression than did either drug alone. Times to onset of, and tolerance to, experimental pain increased with pethidine and buprenorphine, a greater increase occurring when both drugs were combined. There was no evidence that buprenorphine reversed the respiratory depression produced by pethidine, while maintaining analgesia.
在3名健康男性志愿者身上研究了单独给予0.6毫克丁丙诺啡以及在静脉注射哌替啶以达到稳态血哌替啶水平（平均血药浓度0.29 - 0.47微克/毫升）后给予相同剂量丁丙诺啡对呼吸和痛觉的影响。哌替啶和丁丙诺啡均导致通气抑制，且二者合用比单独使用任何一种药物产生的抑制作用更强。对实验性疼痛的起效时间和耐受性随哌替啶和丁丙诺啡而增加，两种药物合用时增加更为明显。没有证据表明丁丙诺啡在维持镇痛的同时能逆转哌替啶所致的呼吸抑制。
