Research Unit of Medical Imaging, Physics and Technology, Faculty of Medicine, University of Oulu, Oulu, Finland.
Center for Life Course Health Research, Faculty of Medicine, University of Oulu, Oulu, Finland.
Sci Rep. 2019 Dec 20;9(1):19497. doi: 10.1038/s41598-019-56186-4.
Only a few previous studies have investigated paraspinal musculature (i.e., multifidus (MF), psoas major (PSM), erector spinae (ES)) in longitudinal, population-based settings. This study aimed to evaluate changes in the cross-sectional area (CSA) of the paraspinal muscles between the ages of 20 and 30 years. The study population consisted of a sub-cohort from the Northern Finland Birth Cohort 1986 (n = 298; 156 men, 142 women). Baseline magnetic resonance imaging was performed at a mean age of 21.3 years and follow-up imaging at 30.6 years. The CSA measurements were performed by tracing the paraspinal muscle outlines individually (MF, ES, PM) and all combined (total muscle area (TMA)) at the L4 cranial endplate level. The longitudinal data analysis was performed using generalized estimating equations modelling. The CSA of MF and ES increased during the follow-up among both sexes (men: MF + 5.7%, p < 0.001; ES + 2.7%, p = 0.001; and women: MF + 10.5%, p < 0.001; ES 9.2%, p = 0.001). The CSA of PM decreased among men (PM -4.0%, p < 0.001) but not among women (PM + 0.5%, p = 0.553). TMA increased significantly only among women (men: +0.5%, p = 0.425; women: +6.5%, p < 0.001). The increases in ES and TMA were more distinct among women than men (p < 0.001). Our study demonstrated clear age- and sex-related changes in paraspinal muscle size in early adulthood.
仅有少数先前的研究调查了脊柱旁肌肉（即多裂肌（MF）、腰大肌（PSM）、竖脊肌（ES））在纵向、基于人群的环境中的变化。本研究旨在评估 20 至 30 岁之间脊柱旁肌肉横截面积（CSA）的变化。研究人群由芬兰北部出生队列 1986 年的一个子队列组成（n=298；156 名男性，142 名女性）。基线磁共振成像在平均年龄 21.3 岁时进行，随访成像在 30.6 岁时进行。CSA 测量是通过单独追踪脊柱旁肌肉轮廓（MF、ES、PM）和所有组合（总肌肉面积（TMA））在 L4 颅端板水平进行的。纵向数据分析使用广义估计方程模型进行。在随访期间，男女的 MF 和 ES CSA 均增加（男性：MF+5.7%，p<0.001；ES+2.7%，p=0.001；女性：MF+10.5%，p<0.001；ES+9.2%，p=0.001）。男性的 PM CSA 减少（PM-4.0%，p<0.001），但女性没有（PM+0.5%，p=0.553）。TMA 仅在女性中显著增加（男性：+0.5%，p=0.425；女性：+6.5%，p<0.001）。ES 和 TMA 的增加在女性中比男性更为明显（p<0.001）。我们的研究表明，在成年早期，脊柱旁肌肉大小存在明显的年龄和性别相关变化。
