Exercise Physiology Department, Sport Sciences Faculty, Shahid Chamran University of Ahvaz, Ahvaz, Iran.
Department of Exercise Physiology, Sport Sciences Faculty, Shahid Chamran University of Ahvaz, Ahvaz, Iran.
Behav Brain Res. 2020 Feb 17;380:112440. doi: 10.1016/j.bbr.2019.112440. Epub 2019 Dec 19.
Endocannabinoid system and cyclooxygenase enzymes are implicated in neuroinflammation-induced cognitive impairment. It is believed that non-pharmacological treatments such as physical exercise affect neural systems that control behavioral responses. This research examined the effects of treadmill aerobic exercise on the expression of cannabinoid receptors and cyclooxygenases against LPS-induced cognitive disorders in the hippocampus tissue of rats. For this purpose, rats received intraperitoneal injection of 0.25 mg/kg LPS or saline for 9 continuous days before exercise training. They again received a single i.p. injection with 0.5 mg/kg LPS or saline on days 20 and 41 after the beginning of exercise. The exercise groups were forced to run on a motorized treadmill 5 days per week for 8 weeks. After the last exercise training session, the water maze test was conducted to measure cognitive function. Finally, the hippocampus tissue samples of rats were removed and used to determine the levels of gene expression using the Real-Time PCR method. Data showed that the LPS-treated rats had longer escape distance and longer escape latency to reach the hidden platform and they spent less time than the other groups in the target quadrant, but exercise training improved them in the LPS + Exe (LPS + exercise) group. Exercise increased the expression of CB1 receptor in the Sal + Exe (saline + exercise) group and reduced the expression of CB2 receptor, COX-2 and mPGES-1 in the LPS + Exe group compared to the Sal + LPS group. The findings indicate that treadmill exercise may be beneficial for improvement of cognitive function by modulating the neuroinflammatory processes.
内源性大麻素系统和环氧化酶参与神经炎症引起的认知障碍。人们认为，非药物治疗，如体育锻炼，会影响控制行为反应的神经系统。这项研究检查了跑步机有氧运动对大麻素受体和环氧化酶表达的影响，以对抗 LPS 诱导的大鼠海马组织认知障碍。为此，大鼠在运动训练前连续 9 天每天腹腔注射 0.25mg/kg LPS 或生理盐水。在运动开始后第 20 天和第 41 天，它们再次接受单次腹腔注射 0.5mg/kg LPS 或生理盐水。运动组每周 5 天被迫在电动跑步机上跑步 8 周。最后一次运动训练后，进行水迷宫测试以测量认知功能。最后，取出大鼠海马组织样本，使用 Real-Time PCR 方法测定基因表达水平。数据显示，LPS 处理的大鼠逃避距离更长，到达隐藏平台的潜伏期更长，它们在目标象限的停留时间比其他组短，但运动训练使 LPS+Exe（LPS+运动）组得到改善。与 Sal+LPS 组相比，运动增加了 Sal+Exe（生理盐水+运动）组中 CB1 受体的表达，降低了 LPS+Exe 组中 CB2 受体、COX-2 和 mPGES-1 的表达。研究结果表明，跑步机运动可能通过调节神经炎症过程有益于改善认知功能。
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