The Nethersole School of Nursing, The Chinese University of Hong Kong, Shatin, Hong Kong.
Support Care Cancer. 2020 Apr;28(4):1607-1630. doi: 10.1007/s00520-019-05215-z. Epub 2019 Dec 24.
To synthesize the characteristics and effects of couple-based intervention on sexuality and the quality of life (QOL) of cancer patients and their intimate partners and its implications for future research and practice.
A systematic review and meta-analysis of randomized and non-randomized controlled studies of interventions was conducted in nine English databases and two Chinese databases, with identification of related studies published in English and Chinese. The quality of the studies was assessed using the tools of the Effective Public Health Practice Project.
A total of 33 articles were identified for systematic review and 23 articles were identified for meta-analysis. For patients, the effect size was 0.42 (Hedges's g, 95% CI = 0.05-0.78, p = 0.03) for physical health. For partners, the effect size was 0.52 (Hedges's g, 95% CI = 0.06-0.98, p = 0.03) for sexual relationships. However, moderate to high heterogeneity was reported. Effects on sexual function, sexual self-concept, and mental health for couples were not significant.
Couple-based interventions had small to medium-sized effects on physical health for cancer patients. Partners could derive medium effects for improvement in sexual relationships from couple-based intervention. Future research should pay more attention to sexual self-concept in cancer patients and target types of cancer that are more likely to compromise sexuality and QOL.
The systematic review and meta-analysis has been registered in PROSPERO with registration number: CRD42019119047.
综合关于基于伴侣的干预对癌症患者及其亲密伴侣的性行为和生活质量（QOL）的特点和效果的研究，并探讨其对未来研究和实践的意义。
在九个英文数据库和两个中文数据库中进行了关于干预措施的随机和非随机对照研究的系统评价和荟萃分析，确定了以英文和中文发表的相关研究。使用有效公共卫生实践项目工具评估研究质量。
共确定了 33 篇系统性综述文章和 23 篇荟萃分析文章。对于患者，生理健康的效应量为 0.42（Hedges's g，95%CI=0.05-0.78，p=0.03）。对于伴侣，性关系的效应量为 0.52（Hedges's g，95%CI=0.06-0.98，p=0.03）。然而，报告了中度到高度的异质性。对夫妻双方的性功能、性自我概念和心理健康的影响不显著。
基于伴侣的干预对癌症患者的生理健康有小到中等程度的影响。伴侣可以从基于伴侣的干预中获得性关系改善的中等效果。未来的研究应更加关注癌症患者的性自我概念，并针对更有可能影响性功能和 QOL 的癌症类型进行研究。
PROSPERO 注册号：本系统评价和荟萃分析已在 PROSPERO 注册，注册号为：CRD42019119047。
