Thana Kanjana, Miller Megan, Chintanawat Rojanee, Reangsing Chuntana
Faculty of Nursing, Chiang Mai University, 110/406 Inthawaroros Road, Chiang Mai, 50200, Thailand.
School of Nursing, University of Wisconsin-Madison, 5117 Signe Skott Cooper Hall, Madison, 53705, USA.
J Cancer Surviv. 2024 Oct 1. doi: 10.1007/s11764-024-01675-3.
Cancer and its treatment can generate substantial psychological distress (depression and anxiety). The objective of this systematic review and meta-analysis is to explore the effectiveness of dyadic interventions on psychological outcomes in cancer patients with active and non-active treatment and to test subgroup analyses to explore the source of heterogeneity affecting effect sizes.
Systematic searching across eight databases identified studies related to dyadic interventions for psychological outcomes of cancer patients published between 2007 and 2022. Rigorous inclusion and exclusion criteria were utilized. Random-effects models were used to compute effect sizes with Hedge's g, forest plot, and Q and I statistics to measure heterogeneity. Moderator analyses were examined.
Eleven primary studies were identified (938 patients with cancer, 56.14 ± 7.29 years old). Overall, dyadic interventions significantly improved depression (g = .36, 95% confidence interval .026 to .68, I = 76%) and anxiety (g = .29, 95% confidence interval 0.14 to .45, I = 0%) compared to controls. With subgroup analyses, fidelity of dyadic interventions, number of weeks across intervention, and number of days after intervention measured were moderators affecting effect sizes.
Dyadic interventions appear to be effective among adults with cancer with active and non-active treatment. Additional research is needed to explore the efficacy of dyadic interventions among more diverse samples and to examine routes for integrating dyadic interventions into practice. IMPLICATIONS FOR CANCER SURVIVORS: Adult with cancer might participate in the dyadic intervention for improving psychological outcomes.
癌症及其治疗可能会引发严重的心理困扰（抑郁和焦虑）。本系统评价和荟萃分析的目的是探讨二元干预对正在接受和未接受积极治疗的癌症患者心理结局的有效性，并进行亚组分析以探究影响效应大小的异质性来源。
通过对八个数据库进行系统检索，确定了2007年至2022年间发表的与二元干预对癌症患者心理结局相关的研究。采用了严格的纳入和排除标准。使用随机效应模型计算效应大小，采用赫奇斯g值、森林图以及Q和I统计量来衡量异质性。进行了调节因素分析。
共纳入11项主要研究（938例癌症患者，年龄56.14±7.29岁）。总体而言，与对照组相比，二元干预显著改善了抑郁（g = 0.36，95%置信区间0.026至0.68，I² = 76%）和焦虑（g = 0.29，95%置信区间0.14至0.45，I² = 0%）。亚组分析显示，二元干预的保真度、干预持续周数以及干预后测量天数是影响效应大小的调节因素。
二元干预似乎对正在接受和未接受积极治疗的成年癌症患者有效。需要进一步研究以探索二元干预在更多样化样本中的疗效，并研究将二元干预纳入实践的途径。对癌症幸存者的启示：成年癌症患者可能参与二元干预以改善心理结局。
