Department of Epidemiology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Department of Radiology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Obesity (Silver Spring). 2020 Feb;28(2):404-411. doi: 10.1002/oby.22695. Epub 2019 Dec 24.
Decreased radiodensity of adipose tissue (AT) located in the visceral AT (VAT), subcutaneous AT (SAT), and intermuscular AT (IMAT) abdominal depots is associated with hyperglycemia, hyperinsulinemia, and insulin resistance independent of AT volumes. These associations were sought in African-ancestry men, who have higher risk for type 2 diabetes and have been underrepresented in previous studies.
This cross-sectional analysis included 505 nondiabetic men of African-Caribbean ancestry (median age: 61 years; median BMI: 26.8 kg/m ) from the Tobago Health Study. AT volumes and radiodensities were assessed using computed tomography, including abdominal (VAT and SAT) and thigh (IMAT) depots. Associations between AT radiodensities were assessed with fasting serum glucose and insulin and with insulin resistance (updated homeostatic model assessment of insulin resistance, HOMA2-IR).
Higher radiodensity in any AT depot was associated with lower log-insulin and log-HOMA2-IR (β range: -0.16 to -0.18 for each; all P < 0.0001). No AT radiodensity was associated with glucose. Thigh IMAT radiodensity associations were independent of, and similar in magnitude to, VAT radiodensities. Model fit statistics suggested that AT radiodensities were a better predictor for insulin and insulin resistance compared with AT volumes in individuals with overweight and obesity.
AT radiodensities at multiple depots are significantly associated with insulin and insulin resistance in African-ancestry men.
与内脏脂肪组织（VAT）、皮下脂肪组织（SAT）和肌间脂肪组织（IMAT）腹部脂肪垫的脂肪组织（AT）的放射密度降低与高血糖、高胰岛素血症和胰岛素抵抗有关，而与 AT 体积无关。这些关联在具有更高 2 型糖尿病风险且在先前研究中代表性不足的非裔男性中进行了研究。
这项横断面分析包括来自多巴哥健康研究的 505 名非裔加勒比裔非糖尿病男性（中位数年龄：61 岁；中位数 BMI：26.8kg/m ）。使用计算机断层扫描评估 AT 体积和放射密度，包括腹部（VAT 和 SAT）和大腿（IMAT）脂肪垫。使用空腹血清葡萄糖和胰岛素以及胰岛素抵抗（更新的稳态模型评估的胰岛素抵抗，HOMA2-IR）评估 AT 放射密度之间的相关性。
任何 AT 储存库中更高的放射密度与更低的 log 胰岛素和 log HOMA2-IR 相关（β 范围：-0.16 至-0.18；均 P<0.0001）。没有 AT 放射密度与葡萄糖相关。大腿 IMAT 放射密度与 VAT 密度的关联是独立的，且大小相似。模型拟合统计数据表明，与超重和肥胖个体的 AT 体积相比，AT 放射密度对胰岛素和胰岛素抵抗的预测更好。
在非裔男性中，多个部位的 AT 放射密度与胰岛素和胰岛素抵抗显著相关。
