Cid Rosie E Curiel, Ortega Alexandra, Visser Ubbo, Kitaigorodsky Marcela, Zheng D Diane, Hincapie Diana, Crenshaw Kirsten Horne, Beaulieu Ashleigh, Bosworth Brooke, Gallardo Liz, Neer Emory, Ramirez Sofia, Crocco Elizabeth A, Georgiou Mike, Sfakianaki Efrosyni, Loewenstein David A
Center for Cognitive Neuroscience and Aging and Department of Psychiatry and Behavioral Sciences, Miller School of Medicine, University of Miami, Miami, FL, USA.
Department of Computer Sciences, University of Miami, Coral Gables, FL, USA.
Adv Alzheimer Dis. 2024 Mar;13(1):11-25. doi: 10.4236/aad.2024.131002. Epub 2024 Mar 29.
Proactive Semantic Interference (PSI) and failure to recover from PSI (frPSI), are novel constructs assessed by the LASSI-L. These measures are sensitive to cognitive changes in early Mild Cognitive Impairment (MCI) and preclinical AD determined by A load using PET. The goal of this study was to compare a new computerized version of the LASSI-L (LASSI-Brief Computerized) to the standard paper-and-pencil version of the test. In this study, we examined 110 cognitively unimpaired (CU) older adults and 79 with amnestic MCI (aMCI) who were administered the paper-and-pencil form of the LASSI-L. Their performance was compared with 62 CU older adults and 52 aMCI participants examined using the LASSI-BC. After adjustment for covariates (degree of initial learning, sex, education, and language of evaluation) both the standard and computerized versions distinguished between aMCI and CU participants. The performance of CU and aMCI groups using either form was relatively commensurate. Importantly, an optimal combination of Cued B2 recall and Cued B1 intrusions on the LASSI-BC yielded an area under the ROC curve of .927, a sensitivity of 92.3% and specificity of 88.1%, relative to an area under the ROC curve of .815, a sensitivity of 72.5%, and a specificity of 79.1% obtained for the paper-and-pencil LASSI-L. Overall, the LASSI-BC was comparable, and in some ways, superior to the paper-and-pencil LASSI-L. Advantages of the LASSI-BC include a more standardized administration, suitability for remote assessment, and an automated scoring mechanism that can be verified by a built-in audio recording of responses.
前瞻性语义干扰（PSI）以及无法从PSI中恢复（frPSI）是由语言学习与记忆筛查量表-长版（LASSI-L）评估的新指标。这些指标对早期轻度认知障碍（MCI）和通过正电子发射断层扫描（PET）检测的Aβ负荷所确定的临床前期阿尔茨海默病（AD）中的认知变化敏感。本研究的目的是将LASSI-L的新计算机化版本（简易计算机化LASSI）与标准纸笔版本进行比较。在本研究中，我们对110名认知未受损（CU）的老年人和79名遗忘型MCI（aMCI）患者进行了LASSI-L纸笔形式的测试。将他们的表现与62名接受简易计算机化LASSI（LASSI-BC）测试的CU老年人和52名aMCI参与者进行比较。在对协变量（初始学习程度、性别、教育程度和评估语言）进行调整后，标准版本和计算机化版本均能区分aMCI和CU参与者。使用两种形式的CU组和aMCI组的表现相对相当。重要的是，简易计算机化LASSI上的线索B2回忆和线索B1侵入的最佳组合产生的ROC曲线下面积为0.927，敏感性为92.3%，特异性为88.1%，而纸笔形式的LASSI-L的ROC曲线下面积为0.815，敏感性为72.5%，特异性为79.1%。总体而言，简易计算机化LASSI与纸笔形式的LASSI-L相当，并且在某些方面更具优势。简易计算机化LASSI的优点包括管理更标准化、适合远程评估以及具有可通过内置的反应录音进行验证的自动评分机制。
