Department of Dermatology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
J Dermatolog Treat. 2021 Nov;32(7):684-692. doi: 10.1080/09546634.2019.1708856. Epub 2020 Mar 6.
Lichen simplex chronicus (LSC) is a disorder characterized by thickened areas of skin from repeated rubbing or scratching. The multifactorial nature of LSC makes management difficult and there are currently no evidence-based guidelines for treatment. We conducted a systematic review of the literature to evaluate treatments for LSC and provide an evidence-based summary of the current treatments as well as highlight novel therapies. A total of 21 studies were included which comprised 682 patients with LSC involving various areas. The most robust evidence was seen with the use of topical corticosteroids ( = 7 RCTs) and limited data suggest benefit with other treatments such as topical immunomodulators, topical antipruritic agents, oral antihistamines, antiepileptics and antidepressants. We also discuss novel treatment approaches using transcutaneous electrical nerve stimulation, focused ultrasound, and phototherapy. Despite emerging evidence there remains a paucity of high-quality studies supporting treatments for LSC and larger controlled trials are needed.
慢性单纯性苔藓（lichen simplex chronicus，LSC）是一种以皮肤反复摩擦或搔抓导致增厚为特征的疾病。LSC 的多因素性质使其治疗变得困难，目前尚无针对其治疗的循证指南。我们对文献进行了系统回顾，以评估 LSC 的治疗方法，并提供当前治疗方法的循证总结，同时突出新的治疗方法。共有 21 项研究纳入了涉及多个部位的 682 例 LSC 患者。使用局部皮质类固醇（ = 7 项 RCT）的证据最充分，而其他治疗方法（如局部免疫调节剂、局部止痒剂、口服抗组胺药、抗癫痫药和抗抑郁药）也有一定疗效，但数据有限。我们还讨论了使用经皮神经电刺激、聚焦超声和光疗等新的治疗方法。尽管新的证据不断涌现，但仍缺乏支持 LSC 治疗的高质量研究，需要进行更大规模的对照试验。
