屋尘螨组分诊断与变应性鼻炎患者变应原免疫治疗疗效之间的关联
Association between component-resolved diagnosis of house dust mite and efficacy of allergen immunotherapy in allergic rhinitis patients.
作者信息
Huang Yanran, Wang Chengshuo, Lin Xi, Lou Hongfei, Cao Feifei, Li Wenhan, Zhang Yuan, Zhang Luo
机构信息
1Department of Otolaryngology Head and Neck Surgery, Beijing TongRen Hospital, Capital Medical University, Beijing, 100730 China.
2Beijing Key Laboratory of Nasal Diseases, Beijing Institute of Otolaryngology, No. 17, HouGou HuTong, Dongcheng District, Beijing, 100005 China.
出版信息
Clin Transl Allergy. 2019 Dec 19;9:64. doi: 10.1186/s13601-019-0305-4. eCollection 2019.
Data regarding clinical relevance of house dust mite (HDM) components over allergen immunotherapy (AIT) for allergic rhinitis (AR) are lacking. 18 adult AR patients receiving HDM-AIT for 52 weeks were followed up to assess serum levels of sIgE and sIgG4 to HDM components. The study showed that Der p1, p2, p23, Der f1 and f2, are important sensitizing components of HDM, of which Der p1 appears to be the most clinically relevant allergenic component for effective AIT.
关于屋尘螨（HDM）成分在变应性鼻炎（AR）的变应原免疫疗法（AIT）中的临床相关性的数据尚缺。对18例接受HDM-AIT治疗52周的成年AR患者进行随访，以评估血清中针对HDM成分的sIgE和sIgG4水平。研究表明，Der p1、p2、p23、Der f1和f2是HDM的重要致敏成分，其中Der p1似乎是有效AIT中最具临床相关性的变应原成分。
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