耳蜗内纤维化及对人工耳蜗生物材料的异物反应。
Intracochlear fibrosis and the foreign body response to cochlear implant biomaterials.
作者信息
Foggia Megan J, Quevedo Rene Vielman, Hansen Marlan R
机构信息
Department of Otolaryngology-Head & Neck Surgery University of Iowa Hospitals and Clinics Iowa City Iowa.
Department of Neurosurgery University of Iowa Hospitals and Clinics Iowa City Iowa.
出版信息
Laryngoscope Investig Otolaryngol. 2019 Nov 13;4(6):678-683. doi: 10.1002/lio2.329. eCollection 2019 Dec.
OBJECTIVE
To report current knowledge on the topic of intracochlear fibrosis and the foreign body response following cochlear implantation (CI).
METHODS
A literature search was performed in PubMed to identify peer-reviewed articles. Search components included "cochlear implant," "Foreign body response (FBR)," and "fibrosis." Original studies and review articles relevant to the topic were included.
RESULTS
Ninety peer-reviewed articles describing the foreign body response or intracochlear fibrosis following CI were included.
CONCLUSIONS
Intracochlear fibrosis following CI represents a significant limiting factor for the success of CI users. Several strategies have been employed to mitigate the foreign body response within the cochlea including drug delivery systems and modifications in surgical technique and electrode design. A better understanding of the FBR has the potential to improve CI outcomes and the next generation of cochlear prostheses.
目的
报告关于人工耳蜗植入（CI）后蜗内纤维化及异物反应这一主题的当前知识。
方法
在PubMed中进行文献检索以识别同行评审文章。检索词包括“人工耳蜗”“异物反应（FBR）”和“纤维化”。纳入了与该主题相关的原始研究和综述文章。
结果
纳入了90篇描述人工耳蜗植入后异物反应或蜗内纤维化的同行评审文章。
结论
人工耳蜗植入后蜗内纤维化是人工耳蜗使用者成功的一个重要限制因素。已采用多种策略来减轻耳蜗内的异物反应，包括药物递送系统以及手术技术和电极设计的改进。对异物反应有更深入的了解有可能改善人工耳蜗植入效果及下一代人工耳蜗假体。
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