针对数量性状通过截断法校正单一确定情况。
Correcting for single ascertainment by truncation for a quantitative trait.
作者信息
Young M R, Boehnke M, Moll P P
机构信息
Department of Biostatistics, School of Public Health, University of Michigan, Ann Arbor 48109.
出版信息
Am J Hum Genet. 1988 Nov;43(5):705-8.
Two methods for correcting for single ascertainment by truncation are compared. These methods are (1) conditioning on the phenotype of the proband and (2) conditioning on the event that the proband phenotype is greater than a threshold. The use of a constraint on model parameters is considered. The lack of robustness of this method to misspecifiction of the constraint has been demonstrated by Rao et al. It is noted that the constraint on model parameters used by Rao et al. is equivalent to an encoding of knowledge derived from a random sample, and an alternative representation of this information that has superior robustness properties is proposed.
比较了两种通过截断来校正单样本确定的方法。这些方法是：（1）以前兆病例的表型为条件；（2）以前兆病例表型大于阈值这一事件为条件。考虑了对模型参数使用约束。Rao等人已经证明了该方法对约束错误指定缺乏稳健性。需要注意的是，Rao等人使用的对模型参数的约束等同于对从随机样本得出的知识进行编码，并且提出了这种信息的一种具有更强稳健性的替代表示。
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