A new kid on the block for acute myeloid leukemia treatment? Homoharringtonine interferes with key pathways in acute myeloid leukemia cells.
作者信息
Bohlander Stefan K
机构信息
Marijana Kumerich Chair in Leukaemia and Lymphoma Research, Leukaemia and Blood Cancer Research Unit, Department of Molecular Medicine and Pathology, The University of Auckland, Auckland, New Zealand
出版信息
Haematologica. 2020 Jan;105(1):7-9. doi: 10.3324/haematol.2019.234880.
Abstract
摘要
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本文引用的文献
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Homoharringtonine exhibits potent anti-tumor effect and modulates DNA epigenome in acute myeloid leukemia by targeting SP1/TET1/5hmC.高三尖杉酯碱通过靶向 SP1/TET1/5hmC 发挥强大的抗肿瘤作用，并调节急性髓系白血病中的 DNA 表观基因组。
Haematologica. 2020 Jan;105(1):148-160. doi: 10.3324/haematol.2018.208835. Epub 2019 Apr 11.
2
New drugs creating new challenges in acute myeloid leukemia.新型药物给急性髓细胞白血病带来新挑战。
Genes Chromosomes Cancer. 2019 Dec;58(12):903-914. doi: 10.1002/gcc.22750. Epub 2019 Apr 11.
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TET-mediated active DNA demethylation: mechanism, function and beyond.TET 介导的活性 DNA 去甲基化：机制、功能及其他。
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Improved Outcomes With Retinoic Acid and Arsenic Trioxide Compared With Retinoic Acid and Chemotherapy in Non-High-Risk Acute Promyelocytic Leukemia: Final Results of the Randomized Italian-German APL0406 Trial.维甲酸和三氧化二砷与维甲酸和化疗治疗非高危急性早幼粒细胞白血病的疗效比较：意大利-德国 APL0406 随机试验的最终结果。
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