• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

弹性蛋白酶触发的聚合物水凝胶中 HS 的释放。

Elastase-triggered HS delivery from polymer hydrogels.

机构信息

Department of Chemistry and Macromolecules Innovation Institute, Virginia Tech, Blacksburg, Virginia 24061, USA.

出版信息

Chem Commun (Camb). 2020 Jan 23;56(7):1085-1088. doi: 10.1039/c9cc08752d.

DOI:10.1039/c9cc08752d
PMID:31894779
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7001589/
Abstract

We report an elastase-responsive, H2S-releasing hydrogel prepared by covalently crosslinking a mixture of carboxymethylcellulose and poly(ethylene glycol) with an elastase-degradable peptide functionalized with an H2S-releasing S-aroylthiooxime (SATO) unit. Addition of elastase triggered a gel-to-sol transition, which exposed SATOs, leading to more and longer H2S release compared to untriggered gels.

摘要

我们报告了一种弹性蛋白酶响应的 H2S 释放水凝胶，该水凝胶通过将羧甲基纤维素和聚乙二醇的混合物与弹性蛋白酶可降解的肽进行共价交联制备，该肽用 H2S 释放 S-芳酰硫肟（SATO）单元进行功能化。加入弹性蛋白酶会引发凝胶到溶胶的转变，从而暴露 SATOs，与未触发的凝胶相比，导致更多和更长时间的 H2S 释放。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ae73/7001589/d57a965e68ac/nihms-1067628-f0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ae73/7001589/834870aa0a6f/nihms-1067628-f0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ae73/7001589/453e71b6c544/nihms-1067628-f0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ae73/7001589/51bcd825386e/nihms-1067628-f0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ae73/7001589/d57a965e68ac/nihms-1067628-f0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ae73/7001589/834870aa0a6f/nihms-1067628-f0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ae73/7001589/453e71b6c544/nihms-1067628-f0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ae73/7001589/51bcd825386e/nihms-1067628-f0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ae73/7001589/d57a965e68ac/nihms-1067628-f0005.jpg

相似文献

1
Elastase-triggered HS delivery from polymer hydrogels.弹性蛋白酶触发的聚合物水凝胶中 HS 的释放。
Chem Commun (Camb). 2020 Jan 23;56(7):1085-1088. doi: 10.1039/c9cc08752d.
2
Human neutrophil elastase responsive delivery from poly(ethylene glycol) hydrogels.聚（乙二醇）水凝胶对人中性粒细胞弹性蛋白酶的响应性递送
Biomacromolecules. 2009 Jun 8;10(6):1484-9. doi: 10.1021/bm9000926.
3
Biodegradable nanocomposite hydrogel structures with enhanced mechanical properties prepared by photo-crosslinking solutions of poly(trimethylene carbonate)-poly(ethylene glycol)-poly(trimethylene carbonate) macromonomers and nanoclay particles.用光交联聚（三亚甲基碳酸酯）-聚（乙二醇）-聚（三亚甲基碳酸酯）大分子单体和纳米粘土颗粒溶液制备的具有增强机械性能的可生物降解纳米复合水凝胶结构。
Acta Biomater. 2012 Dec;8(12):4233-43. doi: 10.1016/j.actbio.2012.09.014. Epub 2012 Sep 17.
4
Supramolecular Tuning of HS Release from Aromatic Peptide Amphiphile Gels: Effect of Core Unit Substituents.超分子调控芳香肽两亲凝胶中 HS 的释放：核心单元取代基的影响。
Biomacromolecules. 2019 Feb 11;20(2):1077-1086. doi: 10.1021/acs.biomac.8b01732. Epub 2019 Jan 24.
5
Thermosensitive Polypeptide Hydrogels as a Platform for ROS-Triggered Cargo Release with Innate Cytoprotective Ability under Oxidative Stress.温敏型多肽水凝胶作为一种平台，用于在氧化应激下具有固有细胞保护能力的 ROS 触发的载药释放。
Adv Healthc Mater. 2016 Aug;5(15):1979-90. doi: 10.1002/adhm.201600292. Epub 2016 Jun 10.
6
Citric acid crosslinked carboxymethylcellulose-poly(ethylene glycol) hydrogel films for delivery of poorly soluble drugs.用于递送难溶性药物的柠檬酸交联羧甲基纤维素-聚乙二醇水凝胶薄膜。
Int J Biol Macromol. 2018 Oct 15;118(Pt A):783-791. doi: 10.1016/j.ijbiomac.2018.06.142. Epub 2018 Jun 28.
7
Hydrogen sulfide-releasing peptide hydrogel limits the development of intimal hyperplasia in human vein segments.硫化氢释放肽水凝胶限制了人静脉段内膜增生的发展。
Acta Biomater. 2019 Oct 1;97:374-384. doi: 10.1016/j.actbio.2019.07.042. Epub 2019 Jul 26.
8
Linker-Regulated HS Release from Aromatic Peptide Amphiphile Hydrogels.连接子调控的芳香肽两亲水凝胶中肝素的释放。
Biomacromolecules. 2020 Mar 9;21(3):1171-1178. doi: 10.1021/acs.biomac.9b01600. Epub 2020 Feb 13.
9
Enzymatically degradable mussel-inspired adhesive hydrogel.酶降解贻贝启发型黏附水凝胶。
Biomacromolecules. 2011 Dec 12;12(12):4326-34. doi: 10.1021/bm201261d. Epub 2011 Nov 21.
10
Poly(ethylene glycol) (PEG)-lactic acid nanocarrier-based degradable hydrogels for restoring the vaginal microenvironment.基于聚乙二醇（PEG）-乳酸纳米载体的可降解水凝胶用于恢复阴道微环境。
J Control Release. 2014 Nov 28;194:301-9. doi: 10.1016/j.jconrel.2014.08.031. Epub 2014 Sep 16.

引用本文的文献

1
Role of hydrogen sulfide in health and disease.硫化氢在健康与疾病中的作用。
MedComm (2020). 2024 Aug 16;5(9):e661. doi: 10.1002/mco2.661. eCollection 2024 Sep.
2
Stimulus-Responsive Hydrogels as Drug Delivery Systems for Inflammation Targeted Therapy.刺激响应水凝胶作为炎症靶向治疗的药物传递系统。
Adv Sci (Weinh). 2024 Jan;11(1):e2306152. doi: 10.1002/advs.202306152. Epub 2023 Nov 20.
3
Hydrogels for Gasotransmitter Delivery: Nitric Oxide, Carbon Monoxide, and Hydrogen Sulfide.用于气体递质传递的水凝胶：一氧化氮、一氧化碳和硫化氢。

本文引用的文献

1
Supramolecular nanostructures with tunable donor loading for controlled HS release.具有可调节供体负载量以实现可控硫化氢释放的超分子纳米结构。
ACS Appl Bio Mater. 2019 Nov 18;2(11):5093-5098. doi: 10.1021/acsabm.9b00768. Epub 2019 Oct 16.
2
Enzyme responsive materials: design strategies and future developments.酶响应性材料：设计策略与未来发展
Biomater Sci. 2013 Jan 30;1(1):11-39. doi: 10.1039/c2bm00041e. Epub 2012 Sep 21.
3
The Benefits of Macromolecular/Supramolecular Approaches in Hydrogen Sulfide Delivery: A Review of Polymeric and Self-Assembled Hydrogen Sulfide Donors.
Macromol Biosci. 2024 Jan;24(1):e2300138. doi: 10.1002/mabi.202300138. Epub 2023 Jul 12.
4
Intelligent polymeric hydrogen sulfide delivery systems for therapeutic applications.用于治疗应用的智能聚合物硫化氢递送系统。
Bioact Mater. 2022 Apr 13;19:198-216. doi: 10.1016/j.bioactmat.2022.03.043. eCollection 2023 Jan.
5
HS-releasing amphiphilic dipeptide hydrogels are potent S. aureus biofilm disruptors.HS 释放两亲性二肽水凝胶是有效的金黄色葡萄球菌生物膜破坏剂。
Biomater Sci. 2020 May 7;8(9):2564-2576. doi: 10.1039/d0bm00241k. Epub 2020 Mar 31.
6
The evolving landscape for cellular nitric oxide and hydrogen sulfide delivery systems: A new era of customized medications.细胞一氧化氮和硫化氢输送系统的不断发展：定制药物的新时代。
Biochem Pharmacol. 2020 Jun;176:113931. doi: 10.1016/j.bcp.2020.113931. Epub 2020 Mar 26.
高分子/超分子策略在硫化氢传递中的应用：聚合物和自组装硫化氢供体的综述。
Antioxid Redox Signal. 2020 Jan 10;32(2):79-95. doi: 10.1089/ars.2019.7864.
4
Supramolecular Tuning of HS Release from Aromatic Peptide Amphiphile Gels: Effect of Core Unit Substituents.超分子调控芳香肽两亲凝胶中 HS 的释放：核心单元取代基的影响。
Biomacromolecules. 2019 Feb 11;20(2):1077-1086. doi: 10.1021/acs.biomac.8b01732. Epub 2019 Jan 24.
5
Hydrogels composed of hyaluronic acid and dendritic ELPs: hierarchical structure and physical properties.由透明质酸和树枝状 ELP 组成的水凝胶：层次结构和物理性质。
Soft Matter. 2019 Jan 30;15(5):917-925. doi: 10.1039/c8sm02450b.
6
Self-Assembled Nanostructures Regulate HS Release from Constitutionally Isomeric Peptides.自组装纳米结构调节结构异构肽中 HS 的释放。
J Am Chem Soc. 2018 Nov 7;140(44):14945-14951. doi: 10.1021/jacs.8b09320. Epub 2018 Oct 27.
7
A Persulfide Donor Responsive to Reactive Oxygen Species: Insights into Reactivity and Therapeutic Potential.一种响应活性氧的过硫化物供体：反应性和治疗潜力的见解。
Angew Chem Int Ed Engl. 2018 May 22;57(21):6324-6328. doi: 10.1002/anie.201803087. Epub 2018 Apr 26.
8
A mini review on hydrogels classification and recent developments in miscellaneous applications.关于水凝胶分类及各种应用中的最新进展的小型综述。
Mater Sci Eng C Mater Biol Appl. 2017 Oct 1;79:958-971. doi: 10.1016/j.msec.2017.05.096. Epub 2017 May 15.
9
Hydrogen sulfide ameliorates chronic renal failure in rats by inhibiting apoptosis and inflammation through ROS/MAPK and NF-κB signaling pathways.硫化氢通过 ROS/MAPK 和 NF-κB 信号通路抑制细胞凋亡和炎症来改善大鼠慢性肾衰竭。
Sci Rep. 2017 Mar 28;7(1):455. doi: 10.1038/s41598-017-00557-2.
10
H2S Attenuates LPS-Induced Acute Lung Injury by Reducing Oxidative/Nitrative Stress and Inflammation.硫化氢通过减轻氧化/硝化应激和炎症反应来减轻脂多糖诱导的急性肺损伤。
Cell Physiol Biochem. 2016;40(6):1603-1612. doi: 10.1159/000453210. Epub 2016 Dec 23.