Harokopio University of Athens, Department of Nutrition and Dietetics, Athens, Greece.
Biomedical Sciences Research Center Al. Fleming, 16672, Vari, Greece.
Obes Surg. 2020 Apr;30(4):1482-1490. doi: 10.1007/s11695-019-04320-6.
Sleeve gastrectomy (SG) and Roux-en-Y gastric bypass (RYGB) are the most frequent bariatric surgery procedures worldwide. In this prospective study, we examined the association of a genetic risk score (GRS) with loss of excess weight after bariatric surgery.
A total of forty-seven morbidly obese Greek patients who underwent SG (81%) or RYGB were recruited, followed up for 2 years and genotyped. Weight loss after surgery was reported as the percentage of excess weight that was lost (%EWL) at 12 and 24 months after surgery. A GRS was constructed based on previously BMI- and WHR-related single nucleotide polymorphisms (SNPs) that were found significantly correlated with weight loss after bariatric surgery in our population. The level of post-surgery %EWL after 12 and 24 months was estimated through two multiple linear regression models that considered the effects of relevant genetic risk variants.
The first proposed model suggested that the predictor variables of GRS, age, and BMI had a significant effect on %EWL12m. GRS was significantly associated with %EWL12m, indicating a 4.618% decrease of %EWL12m per score unit. The second model indicated a positive correlation between %EWL24m and %EWL12m, suggesting that while post-surgery weight loss increased during the first 12 months, an increase was expected in the next 12 months as well. GRS was also significantly associated with %EWL24m, indicating approximately 3% decrease of %EWL24m per score unit.
GRS can be used in the future together with other preoperative parameters in order to predict the outcome of bariatric surgery.
袖状胃切除术（SG）和 Roux-en-Y 胃旁路术（RYGB）是全球最常见的减肥手术。在这项前瞻性研究中，我们研究了遗传风险评分（GRS）与减肥手术后多余体重损失的相关性。
共招募了 47 名接受 SG（81%）或 RYGB 的肥胖希腊患者，随访 2 年并进行基因分型。手术后体重减轻的情况通过手术后 12 个月和 24 个月时的超重体重减轻百分比（%EWL）来报告。根据我们人群中与减肥手术后体重减轻相关的先前与 BMI 和 WHR 相关的单核苷酸多态性（SNP）构建了 GRS。通过考虑相关遗传风险变异的两个多线性回归模型来估计手术后 12 个月和 24 个月的术后%EWL 水平。
第一个提出的模型表明，GRS、年龄和 BMI 等预测变量对%EWL12m 有显著影响。GRS 与%EWL12m 显著相关，表明每单位评分减少 4.618%的%EWL12m。第二个模型表明%EWL24m 与%EWL12m 呈正相关，这表明在最初的 12 个月内手术后体重减轻，在接下来的 12 个月内也会增加。GRS 也与%EWL24m 显著相关，表明每单位评分减少约 3%的%EWL24m。
GRS 可以与其他术前参数一起用于预测减肥手术的结果。
