Shin Seung Won, Yuk Ji Soo, Chun Sang Hun, Lim Yong Taik, Um Soong Ho
School of Chemical Engineering, Sungkyunkwan University, 2066 Seobu-ro, Jangan-gu, Suwon, Gyeonggi-do, 16419, South Korea.
SKKU Advanced Institute of Nanotechnology (SAINT), Sungkyunkwan University, 2066 Seobu-ro, Jangan-gu, Suwon, Gyeonggi-do, 16419, South Korea.
Nano Converg. 2020 Jan 6;7(1):2. doi: 10.1186/s40580-019-0211-4.
Owing to its precise manipulation in nanoscale, DNA as a genetic code becomes a promising and generic material in lots of nanotechnological outstanding exploitations. The nanoscale assembly of nucleic acids in aqueous solution has showed very remarkable capability that is not achievable from any other material resources. In the meantime, their striking role played by effective intracellular interactions have been identified, making these more attractive for a variety of biological applications. Lately, a number of interesting attempts have been made to augment their marvelous diagnostic and therapeutic capabilities, as being integrated with inorganic compounds involving gold, iron oxide, quantum dot, upconversion, etc. It was profoundly studied how structural DNA-inorganic hybrid materials have complemented with each other in a synergistic way for better-graded biological performances. Such hybrid materials consisting of both structural DNAs and inorganics are gradually receiving much attention as a practical and future-oriented material substitute. However, any special review articles highlighting the significant and innovative materials have yet to be published. At the first time, we here demonstrate novel hybrid complexes made of structural DNAs and inorganics for some practical applications.
由于其在纳米尺度上的精确操控，DNA作为一种遗传密码，在许多杰出的纳米技术应用中成为一种有前途的通用材料。核酸在水溶液中的纳米级组装展现出了非凡的能力，这是其他任何材料资源都无法实现的。与此同时，人们已经认识到它们在细胞内有效相互作用中所起的显著作用，这使得它们在各种生物应用中更具吸引力。最近，人们进行了一些有趣的尝试，将它们与包括金、氧化铁、量子点、上转换材料等在内的无机化合物相结合，以增强其出色的诊断和治疗能力。人们深入研究了结构性DNA-无机杂化材料如何以协同方式相互补充，以实现更好的生物性能分级。这种由结构性DNA和无机物组成的杂化材料作为一种实用且面向未来的材料替代品，正逐渐受到广泛关注。然而，尚未有任何突出这些重要且创新材料的专题综述文章发表。我们首次在此展示由结构性DNA和无机物制成的新型杂化复合物，用于一些实际应用。
