Department of Ophthalmology, Hadassah Medical Center, POB 12000, 91120, Jerusalem, Israel.
Graefes Arch Clin Exp Ophthalmol. 2020 Jul;258(7):1359-1365. doi: 10.1007/s00417-019-04598-3. Epub 2020 Jan 6.
Ocular inflammation resulting from a lens pathology is rare in the absence of a cataract or lens trauma because of the lens' immune privilege. The lens can be a source of ocular inflammation when the capsule is broken or when lens proteins leak out through an intact capsule. These uveitides are termed lens-induced uveitis (LIU) and are often associated with advanced cataracts. Cataracts are part of the normal aging process, and in today's world, cataract surgery is a safe and affordable means of vision restoration in the developed world. In patients with neglected cataracts and in the developing world where cataract surgery rates are lower, LIU rates are higher together with the associated complications. In this literature review, we intend to equip the armamentarium of the practicing ophthalmologist with an updated knowledge on the demographic features, clinical characteristics, treatment options, and outcomes of LIU. This is to highlight the need for timely management of cataracts before the development of advanced cataracts and LIU.
由于晶状体的免疫特权，在没有白内障或晶状体创伤的情况下，由晶状体病变引起的眼内炎症很少见。当晶状体囊破裂或晶状体蛋白通过完整的晶状体囊泄漏时，晶状体可能成为眼内炎症的来源。这些葡萄膜炎被称为晶状体诱导性葡萄膜炎（LIU），通常与晚期白内障有关。白内障是正常衰老过程的一部分，在当今世界，白内障手术是发达国家安全且负担得起的视力恢复手段。在被忽视的白内障患者中，以及在白内障手术率较低的发展中国家，LIU 的发生率更高，同时还伴有相关并发症。在本次文献复习中，我们旨在为眼科医生提供更新的知识，包括 LIU 的人口统计学特征、临床特征、治疗选择和结果，以增强他们的知识储备。这突显了在白内障发展为晚期白内障和 LIU 之前及时治疗白内障的必要性。
