颅内动脉瘤性蛛网膜下腔出血：炎症诱导的细胞变化概述。
Aneurysmal Subarachnoid Hemorrhage: an Overview of Inflammation-Induced Cellular Changes.
机构信息
Department of Neurology, University of Virginia, Charlottesville, VA, USA.
Department of Neuroscience, University of Virginia, Charlottesville, VA, USA.
出版信息
Neurotherapeutics. 2020 Apr;17(2):436-445. doi: 10.1007/s13311-019-00829-x.
Abstract
Aneurysmal subarachnoid hemorrhage (SAH) is a devastating disease that leads to poor neurological outcomes and is characterized by both vascular and neural pathologies. Recent evidence demonstrates that inflammation mediates many of the vascular and neural changes observed after SAH. Although most studies focus on inflammatory mediators such as cytokines, the ultimate effectors of inflammation in SAH are parenchymal brain and peripheral immune cells. As such, the present review will summarize our current understanding of the cellular changes of both CNS parenchymal and peripheral immune cells after SAH.
摘要
颅内动脉瘤性蛛网膜下腔出血（SAH）是一种破坏性疾病，导致不良的神经学结局，并以血管和神经病理学为特征。最近的证据表明，炎症介导了 SAH 后观察到的许多血管和神经变化。尽管大多数研究集中在细胞因子等炎症介质上，但 SAH 中炎症的最终效应物是实质脑和外周免疫细胞。因此，本综述将总结我们目前对 SAH 后中枢神经系统实质细胞和外周免疫细胞的细胞变化的理解。
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