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咪达唑仑和右美托咪定用于小型口腔手术清醒镇静后的重要手术参数比较

Comparision of Vital Surgical Parameters, after Administration of Midazolam and Dexmedetomidine for Conscious Sedation in Minor Oral Surgery.

作者信息

Sivasubramani Suryahanthmihiran, Pandyan Deepak Abraham, Ravindran C

机构信息

Department of Oral and Maxillofacial Surgery, Sri Ramachandra Institute of Higher Education and Research, Chennai, Tamil Nadu, India.

出版信息

Ann Maxillofac Surg. 2019 Jul-Dec;9(2):283-288. doi: 10.4103/ams.ams_17_19.

DOI:10.4103/ams.ams_17_19
PMID:31909006
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6933995/
Abstract

AIM

The aim of this study is to compare the efficacy between midazolam and dexmedetomidine in relation to vital parameters, sedation score, pain score, cognitive judgment, and postoperative amnesia to the event in conscious sedation for minor oral surgical procedure.

MATERIALS AND METHODS

A sample size of 30 patients were selected in each group: Group M (midazolam) and Group D (dexmedetomidine).

RESULTS

The mean heart rate (HR) and systolic and diastolic blood pressure measurements were significantly higher in Group M after the 20 min when compared to Group D. The visual analog scale (VAS) scores of pain were not statistically significant between the two groups during the procedure, but at the time of discharge, statistically significant VAS scores were found between the two groups. Nine (30%) patients in Group D and 21 (70%) patients in Group M showed cognitive judgment impairment with the Stroop Color and Word Test at the 30 min.

CONCLUSION

The dexmedetomidine group of patients had reduced blood pressure and HR. No significant differences were noted in oxygen saturation or in respiratory rate between the two drugs. Patients had better sedation, analgesia, lesser cognitive impairment, and amnesia in the dexmedetomidine group.

摘要

目的

本研究旨在比较咪达唑仑和右美托咪定在小型口腔外科手术清醒镇静中对生命体征参数、镇静评分、疼痛评分、认知判断及术后对该事件遗忘情况的疗效。

材料与方法

每组选取30例患者：M组（咪达唑仑）和D组（右美托咪定）。

结果

20分钟后，M组的平均心率（HR）、收缩压和舒张压测量值显著高于D组。术中两组间疼痛视觉模拟量表（VAS）评分无统计学差异，但出院时，两组间VAS评分有统计学差异。30分钟时，D组9例（30%）患者和M组21例（70%）患者在使用Stroop色词测验时出现认知判断损害。

结论

右美托咪定组患者血压和心率降低。两种药物在血氧饱和度或呼吸频率方面无显著差异。右美托咪定组患者镇静、镇痛效果更好，认知损害和遗忘情况更少。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a4ab/6933995/715e6da72c3d/AMS-9-283-g008.jpg
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