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双侧完全性唇腭裂患者的牙齿缺失

Tooth Agenesis in Patients with Complete Bilateral Cleft Lip and Palate.

作者信息

Elhoseiny Yomna O, B Mostafa Raghdaa A, Elkassaby Marwa A, Abou-El-Fotouh Mona M

机构信息

Department of Oral and Maxillofacial Radiology, Faculty of Dentistry, Ain Shams University, Cairo, Egypt.

Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Ain Shams University, Cairo, Egypt.

出版信息

Ann Maxillofac Surg. 2019 Jul-Dec;9(2):359-363. doi: 10.4103/ams.ams_34_19.

DOI:10.4103/ams.ams_34_19
PMID:31909016
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6933966/
Abstract

AIM

The aim of this study was to compare the number of teeth in the premaxilla (cleft area) and to assess the presence of tooth agenesis with the ultimate goal of finding whether differences existed in the two suggested subtypes of nonsyndromic bilateral cleft lip and palate (BCLP) patients.

SETTINGS AND DESIGN

A retrospective comparative study was conducted, where cone- beam computed tomography (CBCT) images of 22 BCLP patients (10 males and 12 females, with age range 8 to 14, mean age 9.6 years) obtained from archive of Cleft Clinic, affiliated to the Oral and Maxillofacial Surgery department, Ain-Shams University, Cairo, Egypt were assessed.

SUBJECTS AND METHODS

CBCT images were divided into two subtypes: Group (P) - this represents BCLP characterized by well-developed (P) prominent premaxilla and SNA >80 ± 2 and Group (R) - this represents BCLP characterized by ill-developed (R) rudimentary premaxilla and SNA <80 ± 2. The number of teeth in the premaxilla was evaluated, and the presence of agenesis in the premaxilla and posterior segments was documented.

STATISTICAL ANALYSIS USED

Unpaired-Student's -test was used to compare the number of teeth among the two groups and to test significance at < 0.05. Intraobserver agreement was assessed using alpha (Cronbach) reliability analysis. A descriptive analysis using percentages was performed to characterize tooth agenesis.

RESULTS

A significant difference was found in the number of teeth in the premaxilla among Group R and Group P. Maxillary lateral incisor showed the highest percentage of agenesis in the two groups followed by the maxillary second premolar.

CONCLUSIONS

The number of teeth might be useful in differentiating different subtypes of nonsyndromic BCLP.

摘要

目的

本研究旨在比较前颌骨(腭裂区域)的牙齿数量,并评估牙发育不全的情况,最终目的是确定非综合征性双侧唇腭裂(BCLP)患者的两种亚型之间是否存在差异。

设置与设计

进行了一项回顾性比较研究,评估了从埃及开罗艾因夏姆斯大学口腔颌面外科附属腭裂诊所存档中获取的22例BCLP患者(10例男性和12例女性,年龄范围8至14岁,平均年龄9.6岁)的锥形束计算机断层扫描(CBCT)图像。

研究对象与方法

CBCT图像分为两个亚型:组(P)——代表具有发育良好(P)突出前颌骨且SNA>80±2的BCLP;组(R)——代表具有发育不良(R)原始前颌骨且SNA<80±2的BCLP。评估前颌骨的牙齿数量,并记录前颌骨和后段牙发育不全的情况。

所用统计分析方法

采用非配对学生t检验比较两组之间的牙齿数量,并在P<0.05时检验显著性。使用α(克朗巴赫)可靠性分析评估观察者间一致性。采用百分比进行描述性分析以表征牙发育不全情况。

结果

在R组和P组之间,前颌骨的牙齿数量存在显著差异。上颌侧切牙在两组中牙发育不全的比例最高,其次是上颌第二前磨牙。

结论

牙齿数量可能有助于区分非综合征性BCLP的不同亚型。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/26bd/6933966/51537842f455/AMS-9-359-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/26bd/6933966/3c1de455c2b7/AMS-9-359-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/26bd/6933966/13ea78536d58/AMS-9-359-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/26bd/6933966/00872f171cf9/AMS-9-359-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/26bd/6933966/51537842f455/AMS-9-359-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/26bd/6933966/3c1de455c2b7/AMS-9-359-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/26bd/6933966/13ea78536d58/AMS-9-359-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/26bd/6933966/00872f171cf9/AMS-9-359-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/26bd/6933966/51537842f455/AMS-9-359-g004.jpg

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本文引用的文献

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Cleft palate with/without cleft lip in French children: radiographic evaluation of prevalence, location and coexistence of dental anomalies inside and outside cleft region.法国儿童的唇裂/腭裂:裂隙区内外牙畸形的发生率、部位和共存的放射学评估。
Clin Oral Investig. 2018 Mar;22(2):689-695. doi: 10.1007/s00784-017-2141-z. Epub 2017 Jun 7.
2
Tooth agenesis and orofacial clefting: genetic brothers in arms?牙齿发育不全与口腔颌面部裂隙:并肩作战的遗传“兄弟”?
Hum Genet. 2016 Dec;135(12):1299-1327. doi: 10.1007/s00439-016-1733-z. Epub 2016 Oct 3.
3
The Facial Growth Pattern and the Amount of Palatal Bone Deficiency Relative to Cleft Size Should Be Considered in Treatment Planning.在治疗计划中应考虑面部生长模式以及相对于腭裂大小的腭骨缺损量。
Plast Reconstr Surg Glob Open. 2016 May 6;4(5):e705. doi: 10.1097/GOX.0000000000000629. eCollection 2016 May.
4
Dental anomalies inside the cleft region in individuals with nonsyndromic cleft lip with or without cleft palate.非综合征性唇裂伴或不伴腭裂患者裂隙区域内的牙齿异常。
Med Oral Patol Oral Cir Bucal. 2016 Jan 1;21(1):e48-52. doi: 10.4317/medoral.20757.
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Common dental anomalies in cleft lip and palate patients.唇腭裂患者常见的牙齿异常。
Malays J Med Sci. 2015 Mar-Apr;22(2):55-60.
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Technical aspects of dental CBCT: state of the art.牙科锥形束计算机断层扫描的技术层面:当前技术水平
Dentomaxillofac Radiol. 2015;44(1):20140224. doi: 10.1259/dmfr.20140224.
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Genetics of cleft lip and cleft palate.唇腭裂的遗传学。
Am J Med Genet C Semin Med Genet. 2013 Nov;163C(4):246-58. doi: 10.1002/ajmg.c.31381. Epub 2013 Oct 4.
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Premaxillary characteristics in complete bilateral cleft lip and palate: A predictor for treatment outcome.双侧完全性唇腭裂的前颌骨特征:治疗效果的预测指标
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Cleft Palate Craniofac J. 2013 Jul;50(4):400-5. doi: 10.1597/11-029. Epub 2011 Oct 5.
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J Indian Assoc Pediatr Surg. 2009 Apr;14(2):55-8. doi: 10.4103/0971-9261.55152.