Zaheer Naauman, Shabaz Maliha, Zaheer Usman, Wyne Amjad H
Naauman Zaheer, BDS, MFDS RCSEd, PhD, CHPE Associate Professor, Oral Biology Department CMH Lahore Medical College & Institute of Dentistry, National University of Medical Sciences, Lahore, Pakistan.
Maliha Shabaz, M.Phil,CHPE Assistant Professor, Oral Biology Department, Department of Restorative Dentistry, Faculty of Dentistry, University of Malaya, Kuala Lumpur, 50603, Malaysia.
Pak J Med Sci. 2024 Jan-Feb;40(3Part-II):421-426. doi: 10.12669/pjms.40.3.7997.
This retrospective, cross-sectional analytical study investigated the incidence of tooth agenesis in cleft lip and palate (CLP) patients. Cone Beam Computed Tomography (CBCT) radiographs of the CLP children were examined for congenitally missing teeth.
This study was conducted at three radiology centers in Lahore, namely, the Pakistan Jinnah MRI and Body Scan Centre, the University of Lahore Radiology Centres, and Fatima Memorial Hospital, from September 2021 to August 2022. The CLP patients were divided into four groups based on the location of the cleft: Cleft Lip and Palate Right (CLPR), Cleft Lip and Palate Left (CLPL), Bilateral Cleft (CLPB), and Midline Cleft (CLPM), inside and outside the cleft region. Two-way ANOVA was employed to compare the means of agenesis. Tukey's test was utilized to ascertain where the difference lies. The significance level was set at ≤ 0.05.
Moreover, a significant number of missing teeth were found inside the cleft. This study observed the CLPL (42.3%) and CLPR (13.6%) types more in number. Maxillary first premolars were found more missing outside the cleft region in CLPL and CLPB types. Although CLPB and CLPM types revealed a pattern of missing teeth, only a few cases were found in this study. Moreover, mean tooth agenesis was highest (4.5 SD.71) in the CLPM group, followed up by CLPB (2.75 SD 2.49), CLPR (1.23 SD 1.27), and CLPL Group (1.15 SD 1.12).
Unilateral cleft lip and palate patients reported significant agenesis patttern compared to bilateral and median cleft cases.
本回顾性横断面分析研究调查了唇腭裂（CLP）患者牙齿发育不全的发生率。对唇腭裂儿童的锥形束计算机断层扫描（CBCT）X线片进行检查，以确定是否存在先天性缺牙。
本研究于2021年9月至2022年8月在拉合尔的三个放射学中心进行，即巴基斯坦真纳MRI与全身扫描中心、拉合尔大学放射学中心和法蒂玛纪念医院。根据腭裂的位置，将唇腭裂患者分为四组：右侧唇腭裂（CLPR）、左侧唇腭裂（CLPL）、双侧腭裂（CLPB）和正中腭裂（CLPM），分别在腭裂区域内外。采用双向方差分析比较发育不全的均值。使用Tukey检验确定差异所在。显著性水平设定为≤0.05。
此外，在腭裂内发现大量缺牙。本研究观察到CLPL型（42.3%）和CLPR型（13.6%）数量更多。在CLPL和CLPB型中，上颌第一前磨牙在腭裂区域外缺失更为常见。虽然CLPB和CLPM型显示出缺牙模式，但本研究中仅发现少数病例。此外，CLPM组的平均牙齿发育不全率最高（4.5 SD.71），其次是CLPB组（2.75 SD 2.49）、CLPR组（1.23 SD 1.27）和CLPL组（1.15 SD 1.12）。
与双侧和正中腭裂病例相比，单侧唇腭裂患者的发育不全模式更为显著。
