Enette Lievyn, Vogel Thomas, Merle Sylvie, Valard-Guiguet Anna-Gaelle, Ozier-Lafontaine Nathalie, Neviere Remi, Leuly-Joncart Claudia, Fanon Jean Luc, Lang Pierre Olivier
1Research Laboratory Mitochondria, Oxidative stress and muscle resistance (MSP, EA-3072), Department of Physiology, Faculty of Medicine, Strasbourg University, Résidence La Yole, bat. B L'Etang Z'abricot, 97200 Strasbourg, France.
2Department of geriatric, University Hospital, Strasbourg, France.
Eur Rev Aging Phys Act. 2020 Jan 6;17:2. doi: 10.1186/s11556-019-0234-1. eCollection 2020.
Evidence suggests that aerobic-type training confers physical benefits and appears to contribute positively to brain health. This study aims to compare the effect of 9-weeks continuous (CAT) to interval aerobic training (IAT) on brain derived neurotrophic factor (BDNF) plasma level, aerobic fitness, cognitive performance, and quality of life among senior with Alzheimer's disease (AD).
52 participants were randomly allocated into three groups (CAT = 14; IAT = 17; and Controls = 21). CAT and IAT consisted of 18 sessions of 30-min cycling, twice a week, over 9 weeks. During the same period, controls were engaged in interactive information sessions. Plasma BDNF level; aerobic fitness parameters (Metabolic equivalent task - METs; Maximal Tolerated Power - MTP); functional capacities (6-Minute Walk Test - 6MWT); cognitive performance (Mini Mental State Examination; Rey auditory verbal learning test; and digit span test) and quality of life (Quality Of Life of Alzheimer's Disease scale - QoL-AD) were measured in all participants at baseline and 9 weeks later. A third plasma BDNF level was quantified following a 4 weeks detraining.
No significant change was measured in terms of plasma BDNF level and cognitive performance after interventions, in all groups compared to baseline. After 9 weeks, CAT and IAT significantly improved aerobic fitness parameters compared to controls (METs: + 0.6 and + 1.0 vs. + 0.4; MTP: + 16 watts and + 20 watts vs. + 10 watts; and functional capacities (6MWT: + 22 m and + 31 m vs. -40 m). Compared to controls, QoL-AD after CAT was improved (+ 2 points; ).
Neither aerobic exercise modalities significantly modified plasma BDNF levels and cognitive performances. CAT and IAT enhanced aerobic fitness and functional capacities in AD patients and CAT their QoL.
ClinicalTrials.gov website (NCT02968875); registration date: 7 September 2016. "Retrospectively registered".
有证据表明，有氧训练能带来身体益处，且似乎对大脑健康有积极作用。本研究旨在比较9周持续有氧训练（CAT）与间歇有氧训练（IAT）对阿尔茨海默病（AD）老年人血浆脑源性神经营养因子（BDNF）水平、有氧适能、认知表现及生活质量的影响。
52名参与者被随机分为三组（CAT组 = 14人；IAT组 = 17人；对照组 = 21人）。CAT组和IAT组在9周内每周进行两次、每次30分钟的骑行训练，共18次。在此期间，对照组参加互动信息课程。在基线和9周后测量所有参与者的血浆BDNF水平、有氧适能参数（代谢当量任务 - METs；最大耐受功率 - MTP）、功能能力（6分钟步行试验 - 6MWT）、认知表现（简易精神状态检查；雷伊听觉词语学习测验；数字广度测验）和生活质量（阿尔茨海默病生活质量量表 - QoL-AD）。在4周停训后对血浆BDNF水平进行第三次量化。
与基线相比，所有组干预后血浆BDNF水平和认知表现均无显著变化。9周后，与对照组相比，CAT组和IAT组的有氧适能参数显著改善（METs：分别增加0.6和1.0，对照组增加0.4；MTP：分别增加16瓦和20瓦，对照组增加10瓦；功能能力（6MWT：分别增加22米和31米，对照组减少40米）。与对照组相比，CAT组后的QoL-AD有所改善（增加2分）。
两种有氧运动方式均未显著改变血浆BDNF水平和认知表现。CAT组和IAT组增强了AD患者的有氧适能和功能能力，CAT组改善了生活质量。
ClinicalTrials.gov网站（NCT02968875）；注册日期：2016年9月7日。“回顾性注册”。
