Bouaziz Walid, Schmitt Elise, Vogel Thomas, Lefebvre François, Leprêtre Pierre-Marie, Kaltenbach Georges, Geny Bernard, Lang Pierre-Olivier
Geriatric Department, University Hospitals of Strasbourg, Strasbourg, France.
Research Laboratory Mitochondria, Oxidative stress and muscle resistance (MSP, EA-3072), Department of Physiology, Faculty of Medicine, Strasbourg University, Strasbourg, France.
Int J Clin Pract. 2019 Jan;73(1):e13219. doi: 10.1111/ijcp.13219. Epub 2018 Jul 2.
Interval aerobic training programme with active recovery bouts (IATP-R) has shown to improve tolerance to IATP among seniors. However, data concerning its benefits for seniors' health are still limited.
The purpose of this study was to examine the effects of IATP-R on seniors' health status.
Sedentary volunteers (n = 60, aged ≥70 years) were randomly assigned to either IATP-R or maintained sedentary lifestyle for 9.5 weeks. IATP-R consisted of 30-minute cycling (6 × 4 minutes at first ventilatory threshold (VT ) intensity + 1 minute at 40% of VT ) twice a week. Cognitive and functional performances were assessed with the Trail Making Test (TMT-A; TMT-B); Paced Auditory Serial Addition Test (PASAT); Timed Up and Go (TUG) test; 6-Minute Walk Test (6-MWT); one-leg balance test; and the Short Physical Performance Battery (SPPB) tests, respectively. QoL and anxiety/depression status were measured by the Short Form-12 and the Goldberg's Scale, respectively. All participants were assessed at baseline and 9.5 weeks later.
Compared to controls, IATP-R improved cognitive functions (TMT-A: +1.5% vs -21.5%; TMT-B: +0.9% vs -13.3%; PASAT: +1.4% vs -14.6%; semantic fluency: -1.1% vs +11.7%), functional performance (TUG: +5.4% vs -16.5%; 6-MWT: -3.2% vs +11.5%; SPPB: -3.2% vs +14.6%; One-leg balance: -16.3% vs +25.0%); QoL (physical health: -13.3% vs +23.1%; mental health: -7.1% vs +8.2%); and depressive symptoms (+26.3% vs -42.8%). Significant impacts were measured neither on letter modality of fluency tasks nor on anxiety score.
These data showed that IATP-R is an effective training programme to improve functional and cognitive performances, mental health and well-being in sedentary seniors. Trial registration ClinicalTrials.gov NCT02263573. Registered October 1, 2014.
包含主动恢复时段的间歇有氧训练计划（IATP-R）已被证明可提高老年人对间歇有氧训练的耐受性。然而，关于其对老年人健康益处的数据仍然有限。
本研究的目的是检验IATP-R对老年人健康状况的影响。
久坐不动的志愿者（n = 60，年龄≥70岁）被随机分配到IATP-R组或维持久坐不动的生活方式9.5周。IATP-R包括每周两次30分钟的骑行（6次，每次4分钟，强度为第一通气阈值（VT）+ 1分钟，强度为VT的40%）。分别通过连线测验（TMT-A；TMT-B）、听觉连续加法测验（PASAT）、计时起立行走测试（TUG）、6分钟步行测试（6-MWT）、单腿平衡测试和简短体能状况量表（SPPB）测试评估认知和功能表现。生活质量和焦虑/抑郁状态分别通过简明健康调查量表12项（Short Form-12）和戈德堡量表进行测量。所有参与者在基线和9.5周后进行评估。
与对照组相比，IATP-R改善了认知功能（TMT-A：+1.5%对-21.5%；TMT-B：+0.9%对-13.3%；PASAT：+1.4%对-14.6%；语义流畅性：-1.1%对+11.7%）、功能表现（TUG：+5.4%对-16.5%；六分钟步行测试：-3.2%对+11.5%；SPPB：-3.2%对+14.6%；单腿平衡：-16.3%对+25.0%）、生活质量（身体健康：-13.3%对+23.1%；心理健康：-7.1%对+8.2%）以及抑郁症状（+26.3%对-42.8%）。在流畅性任务的字母模式或焦虑评分方面均未测量到显著影响。
这些数据表明，IATP-R是一种有效的训练计划，可改善久坐不动的老年人的功能和认知表现、心理健康及幸福感。试验注册ClinicalTrials.gov NCT02263573。于2014年10月1日注册。
