Yan Ting, Wang Anhua, Hu Gaosheng, Jia Jingming
School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, China.
Nat Prod Res. 2021 Oct;35(20):3351-3359. doi: 10.1080/14786419.2019.1700245. Epub 2020 Jan 13.
A new fatty acid-spirostan steroid glycoside ester, a new cholestane glycoside and a new stilbene trimer, along with three known steroidal saponins, were isolated from the 70% EtOH extract of the roots and rhizomes of Maxim. The structure of isolated compounds was elucidated by spectroscopic analysis. Compound were assessed for their cytotoxicity against cancer cell lines (MCF-7, HCT-116, DU-145, SGC-7901, MCF-7/ADR, K562/ADR), and the result showed that compound was highly toxic to six human tumor cell lines.
从Maxim.的根和根茎的70%乙醇提取物中分离出一种新的脂肪酸-螺甾烷甾体糖苷酯、一种新的胆甾烷糖苷和一种新的芪三聚体，以及三种已知的甾体皂苷。通过光谱分析阐明了分离化合物的结构。评估了化合物对癌细胞系（MCF-7、HCT-116、DU-145、SGC-7901、MCF-7/ADR、K562/ADR）的细胞毒性，结果表明该化合物对六种人类肿瘤细胞系具有高毒性。
