Xie Jianwei, Wang Kunjun, Gao Xiaoxu, Wang Anhua, Hu Gaosheng, Yan Ting, Jia Jingming
School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, China.
Nat Prod Res. 2024 Aug;38(15):2543-2552. doi: 10.1080/14786419.2023.2188211. Epub 2023 Mar 16.
Two undescribed polyacetylated 18-norspirostanol saponins, trilliumosides J () and 21-deoxyepitrillenoside C (), a novel resveratrol aneuploid, 3a,3b-dimethoxyhopeachinol B () along with four known steroidal saponins (), were isolated from the 70% EtOH extract of the roots and rhizomes of The structures of isolated compounds were elucidated by spectroscopic analysis and chemical degradation. Compounds , and had potential cytotoxic activity against MCF-7, with IC values 86.38 ± 2.59 μM, 56.20 ± 1.57 μM and 45.70 ± 0.63 μM.
从延龄草的根状茎70%乙醇提取物中分离得到两个未描述的多乙酰化18-降螺甾烷醇皂苷,延龄草皂苷J()和21-脱氧表延龄草皂苷C(),一个新的白藜芦醇非整倍体,3a,3b-二甲氧基何帕酚B()以及四个已知甾体皂苷()。通过光谱分析和化学降解阐明了分离得到化合物的结构。化合物、和对MCF-7具有潜在细胞毒性活性,IC值分别为86.38±2.59μM、56.20±1.57μM和45.70±0.63μM。