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低镁血症诱发的复发性小脑共济失调:一例成功治疗的有趣病例

Hypomagnesaemia induced recurrent cerebellar ataxia: an interesting case with successful management.

作者信息

Kumar Singh Saraj, Khushbu Goel, Dev Mukherji Joy

机构信息

Department of Neurosurgery, AIIMS Patna, Patna, Bihar 801507 India.

2Department of Neurology, Max Super Speciality Hospital, Saket, New Delhi, 110017 India.

出版信息

Cerebellum Ataxias. 2020 Jan 8;7:1. doi: 10.1186/s40673-019-0110-9. eCollection 2020.

DOI:10.1186/s40673-019-0110-9
PMID:31934342
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6950808/
Abstract

PURPOSE

Severe Hypomagnesaemia is a rare biochemical findings utilized for identifying the etiology of cerebellar ataxia. It requires a high degree of suspicion to diagnose. MRI findings are often nonspecific.

METHODS

The author presents a case of 38 yrs. old male patient presented with vomiting, gait imabalance and nystagmus. Biochemical investigations lead to severe hypomagnesaemia. Also MRI findings were matched suggesting of hyperintesity in left cerebellar hemisphere.

RESULTS

Patient was treated with magnesium infusion which leads to recovery of patient. Again the same symptomology was repeated after 3 months and disappearance after same treatment. Offending cause was diagnosed and proton pump inhibitors stopped.

CONCLUSION

Severe Hypomagnesaemia is a rare but treatable cause if diagnosed at right time. It requires a high degree of suspicion to diagnose it. Measurement of serum magnesium levels should always be kept in back of mind if definite management of cerebellar symptoms has to be done.

摘要

目的

严重低镁血症是一种罕见的生化检查结果,用于确定小脑共济失调的病因。诊断需要高度怀疑。MRI表现通常不具有特异性。

方法

作者报告一例38岁男性患者,表现为呕吐、步态不稳和眼球震颤。生化检查发现严重低镁血症。MRI表现也相符,提示左侧小脑半球高信号。

结果

患者接受镁输注治疗后康复。3个月后同样的症状再次出现,经同样治疗后消失。确定了病因并停用了质子泵抑制剂。

结论

严重低镁血症虽然罕见,但如果及时诊断是可治疗的病因。诊断需要高度怀疑。如果要对小脑症状进行明确治疗,应始终牢记检测血清镁水平。

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本文引用的文献

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Proton pump inhibitor-induced hypomagnesemia: A new challenge.质子泵抑制剂所致低镁血症:一项新挑战。
World J Nephrol. 2012 Dec 6;1(6):151-4. doi: 10.5527/wjn.v1.i6.151.
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Cerebellar syndrome in chronic cyclic magnesium depletion.
Cerebellum. 2013 Aug;12(4):587-8. doi: 10.1007/s12311-012-0431-1.
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Severe hypomagnesemia associated with reversible subacute ataxia and cerebellar hyperintensities on MRI.严重低镁血症伴可逆性亚急性共济失调及MRI显示小脑高信号。
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Importance of Magnesium Status in COVID-19.镁状态在2019冠状病毒病中的重要性。
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Hypomagnesemia, a Rare Cause of Reversible Ataxia.低镁血症,一种可引起共济失调的罕见病因。
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Front Neurol. 2020 Sep 8;11:968. doi: 10.3389/fneur.2020.00968. eCollection 2020.
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Biol Trace Elem Res. 2011 Aug;142(2):127-9. doi: 10.1007/s12011-010-8757-3. Epub 2010 Jul 7.
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