Florentin Matilda, Elisaf Moses S
Matilda Florentin, Moses S Elisaf, Department of Internal Medicine, Medical School, University of Ioannina, Ioannina 45110, Greece.
World J Nephrol. 2012 Dec 6;1(6):151-4. doi: 10.5527/wjn.v1.i6.151.
Proton pump inhibitors (PPIs) are commonly used in clinical practice for the prevention and treatment of peptic ulcer, gastritis, esophagitis and gastroesophageal reflux. Hypomagnesemia has recently been recognized as a side effect of PPIs. Low magnesium levels may cause symptoms from several systems, some of which being potentially serious, such as tetany, seizures and arrhythmias. It seems that PPIs affect the gastrointestinal absorption of magnesium. Clinicians should be vigilant in order to timely consider and prevent or reverse hypomagnesemia in patients who take PPIs, especially if they are prone to this electrolyte disorder.
质子泵抑制剂（PPIs）在临床实践中常用于预防和治疗消化性溃疡、胃炎、食管炎和胃食管反流。低镁血症最近被认为是PPIs的一种副作用。低镁水平可能导致多个系统出现症状，其中一些可能很严重，如手足搐搦、癫痫发作和心律失常。PPIs似乎会影响镁在胃肠道的吸收。临床医生应保持警惕，以便及时考虑并预防或纠正服用PPIs患者的低镁血症，尤其是那些容易出现这种电解质紊乱的患者。
