Laboratory of Inborn Errors of Immunity, Department of Immunology, Microbiology and Transplantation, KU Leuven, Leuven, Belgium.
Laboratory of Inborn Errors of Immunity, Department of Immunology, Microbiology and Transplantation, KU Leuven, Leuven, Belgium; Department of Pediatrics, University Hospitals Leuven, Leuven, Belgium.
Curr Opin Immunol. 2020 Feb;62:79-90. doi: 10.1016/j.coi.2019.12.002. Epub 2020 Jan 11.
The germline encoded innate immunity governs eukaryotic host defense through both hematopoietic and non-hematopoietic cells, whereas adaptive immunity actions mainly via T cells and B cells characterized by their somatic genetic diversification of antigen-specific responses. Human inborn errors of innate immunity typically underlie infectious diseases. Disturbed innate immunity can additionally result in auto-inflammation. Here, we review inborn errors of innate immunity that have been recently discovered as well as new insights into previously described inborn errors of innate immunity.
种系编码的固有免疫通过造血细胞和非造血细胞来控制真核宿主防御，而适应性免疫作用主要通过 T 细胞和 B 细胞来实现，其特征是抗原特异性反应的体细胞遗传多样化。人类固有免疫的先天缺陷通常是由传染病引起的。此外，固有免疫的紊乱还会导致自身炎症。在这里，我们回顾了最近发现的固有免疫先天缺陷，以及对以前描述的固有免疫先天缺陷的新见解。
