Si-Tahar M, Touqui L, Chignard M
Institut Pasteur, Unité de Défense innée et Inflammation, Paris, France.
Clin Exp Immunol. 2009 May;156(2):194-8. doi: 10.1111/j.1365-2249.2009.03893.x. Epub 2009 Mar 2.
Innate immunity is the host's first line of defence against infection. In this review, we present the innate immune response implicated in three examples of pulmonary infection of viral, fungal and bacterial origin. We show that this defence against infection can be a double-edged sword. Thus, the same cells, molecules and mechanisms involved in this protective process can also be involved in deleterious inflammation. A delicate balance between immunity and inflammation is therefore required, making it possible to fight pathogens effectively while limiting inflammation that might be damaging to the host.
固有免疫是宿主抵御感染的第一道防线。在本综述中，我们介绍了与病毒、真菌和细菌源性肺部感染的三个例子相关的固有免疫反应。我们表明，这种抗感染防御可能是一把双刃剑。因此，参与这一保护过程的相同细胞、分子和机制也可能参与有害炎症。因此，需要在免疫和炎症之间保持微妙的平衡，以便在限制可能对宿主造成损害的炎症的同时有效地对抗病原体。
