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基于照料者报告的患者症状对痴呆进行分期:来自潜在类别分析的启示。

Staging dementia based on caregiver reported patient symptoms: Implications from a latent class analysis.

机构信息

Research Division, Institute of Mental Health, Singapore.

Department of Geriatric Psychiatry, Institute of Mental Health, Singapore.

出版信息

PLoS One. 2020 Jan 15;15(1):e0227857. doi: 10.1371/journal.pone.0227857. eCollection 2020.

Abstract

BACKGROUND

Tailoring interventions to the needs of caregivers is an important feature of successful caregiver support programs. To improve cost-effectiveness, group tailoring based on the stage of dementia could be a good alternative. However, existing staging strategies mostly depend on trained professionals.

OBJECTIVE

This study aims to stage dementia based on caregiver reported symptoms of persons with dementia.

METHODS

Latent class analysis was used. The classes derived were then mapped with disease duration to define the stages. Logistic regression with receiver operating characteristic curve was used to generate the optimal cut-offs.

RESULTS

Latent class analysis suggested a 4-class solution, these four classes were named as early (25.9%), mild (25.2%), moderate (16.7%) and severe stage (32.3%). The stages based on the cut-offs generated achieved an overall accuracy of 90.8% compared to stages derived from latent class analysis.

CONCLUSION

The current study confirmed that caregiver reported patient symptoms could be used to classify persons with dementia into different stages. The new staging strategy is a good complement of existing dementia clinical assessment tools in terms of better supporting informal caregivers.

摘要

背景

根据照顾者的需求定制干预措施是成功的照顾者支持计划的一个重要特征。为了提高成本效益,基于痴呆症阶段的小组定制可能是一个很好的选择。然而,现有的分期策略大多依赖于经过培训的专业人员。

目的

本研究旨在根据痴呆症患者的照顾者报告的症状对痴呆症进行分期。

方法

使用潜在类别分析。然后将派生的类别与疾病持续时间进行映射,以定义阶段。使用具有接收者操作特征曲线的逻辑回归生成最佳截止值。

结果

潜在类别分析表明存在 4 个类别解决方案,这四个类别分别命名为早期(25.9%)、轻度(25.2%)、中度(16.7%)和重度(32.3%)。与基于潜在类别分析得出的阶段相比,基于生成的截止值得出的阶段总体准确率达到 90.8%。

结论

本研究证实,照顾者报告的患者症状可用于将痴呆症患者分为不同阶段。新的分期策略是对现有痴呆症临床评估工具的很好补充,可更好地为非正式照顾者提供支持。

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