Ríos-Osorio Néstor, Muñoz-Alvear Hernan Darío, Montoya Cañón Santiago, Restrepo-Mendez Silvia, Aguilera-Rojas Sandra E, Jiménez-Peña Oscar, García-Perdomo Herney Andrés
Quintessence Int. 2020;51(2):100-107. doi: 10.3290/j.qi.a43865.
The purpose of the present study was to assess the influence of type 2 diabetes mellitus (DM) on the evolution of pulpal and periapical pathology.
Two reviewers independently conducted a systematic search for articles published between 1 January 2001 and 31 December 2018 on MEDLINE/PubMed, ISI Web of Science, and Scopus databases. An additional manual search was also carried out.
Ten studies fulfilling the inclusion criteria were included in the review (two longitudinal studies with 1-year follow-up comparing the success of primary root canal treatment between type 2 diabetic patients and non-diabetic patients, and eight cross-sectional studies). Analysis of the ten studies showed that inadequate control of type 2 DM may predispose and influence the inflammatory pulpal and periapical disease evolution.
The present systematic review suggests that there are biologic bases to suggest that type 2 DM may act as a risk factor for developing an endodontic pathology, affecting the course of the disease in terms of susceptibility, prevalence, progression, and tissue healing capacity as a consequence of a disrupted immune response. However, more well-designed clinical investigations carrying out suitable research methodologies are needed to elucidate the influence of type 2 DM on the pulpal and periapical disease evolution.
本研究旨在评估2型糖尿病（DM）对牙髓及根尖周病变发展的影响。
两名评审员独立对2001年1月1日至2018年12月31日期间发表在MEDLINE/PubMed、ISI科学网和Scopus数据库上的文章进行系统检索。还进行了额外的手工检索。
本综述纳入了10项符合纳入标准的研究（两项为期1年随访的纵向研究，比较2型糖尿病患者和非糖尿病患者根管初次治疗的成功率，以及8项横断面研究）。对这10项研究的分析表明，2型糖尿病控制不佳可能易引发并影响牙髓及根尖周炎症性疾病的发展。
本系统综述表明，有生物学依据提示2型糖尿病可能是牙髓病发病的危险因素，由于免疫反应紊乱，在易感性、患病率、进展及组织愈合能力方面影响疾病进程。然而，需要更多采用合适研究方法的精心设计的临床研究来阐明2型糖尿病对牙髓及根尖周疾病发展的影响。
