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[受辐照细胞和细胞群体中DNA合成过程的数学建模。受辐照哺乳动物细胞中DNA链起始和延伸的建模]

[Mathematical modeling of the processes of DNA synthesis in irradiated cells and cell populations. Modeling of the initiation and elongation of DNA chains in irradiated mammalian cells].

作者信息

Synzynys B I, Shapovalova E V

出版信息

Radiobiologiia. 1988 Sep-Oct;28(5):597-600.

PMID:3194489
Abstract

Dose-dependence of DNA synthesis inhibition in cells of HeLa suspension culture, bone marrow and thymus of mice was investigated. A contribution of inhibition of replicon synthesis and DNA chain elongation to the total effect of DNA synthesis inhibition by gamma-radiation was estimated by mathematical simulation. The method is proposed for evaluation of Di that characterizes cell radiosensitivity. Radiosensitivity of HeLa cells after preirradiation or exposure to 5-fluorodeoxyuridine was assessed.

摘要

研究了γ射线对HeLa悬浮培养细胞、小鼠骨髓细胞和胸腺细胞DNA合成抑制的剂量依赖性。通过数学模拟估算了复制子合成抑制和DNA链延伸抑制对γ射线抑制DNA合成总效应的贡献。提出了评估表征细胞放射敏感性的Di的方法。评估了预照射或暴露于5-氟脱氧尿苷后HeLa细胞的放射敏感性。

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1
[Mathematical modeling of the processes of DNA synthesis in irradiated cells and cell populations. Modeling of the initiation and elongation of DNA chains in irradiated mammalian cells].[受辐照细胞和细胞群体中DNA合成过程的数学建模。受辐照哺乳动物细胞中DNA链起始和延伸的建模]
Radiobiologiia. 1988 Sep-Oct;28(5):597-600.
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[Suppression of the initiation of DNA synthesis as an index of cellular radiosensitivity].[将DNA合成起始的抑制作为细胞放射敏感性指标]
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Inhibition of DNA synthesis and G1/S-phase transition in normal human fibroblasts elicited by a heat-labile trans-acting factor in gamma-irradiated HeLa cell extracts.γ射线照射的HeLa细胞提取物中一种热不稳定反式作用因子引起的正常人成纤维细胞DNA合成及G1/S期转换的抑制。
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[Dynamics and dose-dependent changes in RNA and DNA synthesis in the thymus of irradiated animals].[受辐照动物胸腺中RNA和DNA合成的动态变化及剂量依赖性变化]
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[DNA replication in mammalian cells after exposure to factors of a physical, chemical or biological nature. III. 5-Fluorodeoxyuridine induces DNA synthesis in cells not suppressed by gamma irradiation].[暴露于物理、化学或生物性质因素后哺乳动物细胞中的DNA复制。III. 5-氟脱氧尿苷诱导未被γ射线抑制的细胞中的DNA合成]
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[DNA replication in mammalian cells after the action of physical, chemical or biological factors. VI. The recovery of DNA synthesis in a culture of irradiated cells].[物理、化学或生物因素作用后哺乳动物细胞中的DNA复制。VI. 受辐照细胞培养物中DNA合成的恢复]
Tsitologiia. 1991;33(8):75-81.
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Delayed inhibition of subchromosomal DNA synthesis in V-79 Chinese hamster cells after gamma irradiation.γ射线照射后V - 79中国仓鼠细胞中亚染色体DNA合成的延迟抑制
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Radiobiologiia. 1986 Nov-Dec;26(6):728-32.