Department of Brain and Cognitive Science, Seoul National University College of Natural Sciences, Seoul, Korea.
Department of Neuropsychiatry, Seoul National University Bundang Hospital, Seongnam, Korea.
Sci Rep. 2020 Jan 16;10(1):421. doi: 10.1038/s41598-019-57381-z.
Coffee consumption is associated with cerebral hypoperfusion that may contribute to the development of cerebral white matter hyperintensities (WMH). We investigated the effect of lifetime coffee consumption on the volume of WMH (V) in late life, and compared the effect between men and women since caffeine clearance may be different between sexes. We enrolled 492 community-dwelling cognitively normal elderly individuals (73.4 ± 6.7 years old on average) from the Korean Longitudinal Study on Cognitive Aging and Dementia. We evaluated their patterns and amounts of coffee consumption using a study-specific standardized interview and estimated cerebral V by automatic segmentation of brain fluid-attenuated inversion recovery sequence magnetic resonance images. Higher cumulative lifetime coffee consumption was associated with higher logV in both sexes (p = 0.030). The participants who consumed more than 2 cups of coffee per day on average in their lifetime showed higher logV in late life than those who consumed less. When both sexes were analyzed separately, these coffee-logV associations were found only in women, although the volumes of brain and white matter of women were smaller than those of men. Our findings suggest that prolonged high coffee consumption may be associated with the risk of WMH in late life.
咖啡的摄入与脑灌注不足有关，而后者可能会导致脑白质高信号（WMH）的发展。我们研究了终生咖啡摄入量对老年人 WMH 体积（V）的影响，并比较了男性和女性之间的影响，因为咖啡因的清除率在性别之间可能有所不同。我们从韩国认知衰老和痴呆纵向研究中招募了 492 名居住在社区、认知正常的老年人（平均年龄为 73.4±6.7 岁）。我们使用特定于研究的标准化访谈评估了他们的咖啡饮用模式和数量，并通过自动分割脑液体衰减反转恢复序列磁共振图像来估计脑 V。在两性中，更高的累积终生咖啡摄入量与更高的 logV 相关（p=0.030）。在一生中平均每天饮用超过 2 杯咖啡的参与者在晚年的 logV 高于饮用较少咖啡的参与者。当分别分析男女时，这些咖啡-logV 关联仅在女性中发现，尽管女性的脑和白质体积小于男性。我们的研究结果表明，长期大量饮用咖啡可能与晚年 WMH 的风险有关。
