Department of Psychiatry, Seoul National University College of Medicine, Seoul, South Korea.
Department of Psychiatry, SMG-SNU Boramae Medical Center, Seoul, South Korea.
Sci Rep. 2022 Feb 28;12(1):3296. doi: 10.1038/s41598-022-07325-x.
The association between serum free hemoglobin (sfHb) level and white matter hyperintensity (WMH) volume is controversial. This study is to examine this association considering nonlinearity, sex dimorphism, and WMH type. We enrolled 704 older adults among the participants of the Korean Longitudinal Study on Cognitive Aging and Dementia and visitors to the Dementia Clinic of Seoul National University Bundang Hospital. We measured sfHb level in the venous blood and WMH volume (V) using fluid-attenuated inversion recovery magnetic resonance images. The association between sfHb level and periventricular V was linear in men (linear regression; β = - 0.18, p = 0.006) and U-shaped in women (restricted cubic spline; F = 6.82, p < 0.001). sfHb level was not associated with deep V in either sex. These findings were also observed in participants without anemia. To conclude, sfHb level is associated with periventricular V in older adults of both sexes. Maintaining an optimal sfHb level may contribute to the prevention of WMH.
血清游离血红蛋白 (sfHb) 水平与脑白质高信号 (WMH) 体积之间的关系存在争议。本研究旨在考虑非线性、性别二态性和 WMH 类型，来检验这种关联。我们纳入了韩国认知老化与痴呆纵向研究的 704 名老年人和首尔国立大学盆唐医院痴呆诊所的来访者。我们使用液体衰减反转恢复磁共振成像测量了静脉血中的 sfHb 水平和 WMH 体积 (V)。在男性中，sfHb 水平与脑室周围 V 呈线性关系（线性回归；β=-0.18，p=0.006），而在女性中呈 U 型关系（限制立方样条；F=6.82，p<0.001）。在两性中，sfHb 水平与深部 V 均无相关性。这些发现也存在于没有贫血的参与者中。总之，在老年男性和女性中，sfHb 水平与脑室周围 V 相关。维持最佳 sfHb 水平可能有助于预防 WMH。
