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基于蒙特卡罗模拟的镥-177单光子发射计算机断层成像中的能量窗与准直器优化

Energy Window and Collimator Optimization in Lutetium-177 Single-photon Emission Computed Tomography Imaging using Monte Carlo Simulation.

作者信息

Asmi Hicham, Bentayeb Farida, Bouzekraoui Youssef, Bonutti Faustino, Douama Sanae

机构信息

Department of Physics, LPHE, Modeling and Simulations, Faculty of Science, Mohammed, V University, Rabat, Morocco.

Department of Medical Physics, Academic Hospital of Udine, Udine, Italy.

出版信息

Indian J Nucl Med. 2020 Jan-Mar;35(1):36-39. doi: 10.4103/ijnm.IJNM_121_19. Epub 2019 Dec 31.

DOI:10.4103/ijnm.IJNM_121_19
PMID:31949367
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6958958/
Abstract

INTRODUCTION

In lutetium-177 (Lu-177) single-photon emission computed tomography (SPECT) imaging, the accuracy of activity quantification is degraded by penetrated and scattered photons. We assessed the scattered photon fractions in order to determine the optimal situation and development of correction method. This study proposes to compare the image quality that can be achieved by three collimators.

MATERIALS AND METHODS

Siemens Medical System Symbia fitted with high-energy (HE), medium-energy (ME), and low-energy high-resolution collimators was simulated using the SIMIND Monte Carlo code simulation code. Counts were collected in three different main-energy window widths (20%, 15%, and 10%) for Lu-177 point source. Primary and scattered point spread functions and also geometric, penetration, scattering were drawn and analyzed.

RESULTS

In Lu-177 imaging, a 20% of main-energy window and ME collimator were found to be optimal. HE collimator can be used when the resolution is not required.

CONCLUSION

These results provide the optimal energy window and collimator in Lu-177 SPECT imaging and will help the quantification of Lu-177.

摘要

引言

在镥 - 177（Lu - 177）单光子发射计算机断层扫描（SPECT）成像中，穿透光子和散射光子会降低活度定量的准确性。我们评估了散射光子分数，以确定校正方法的最佳情况和发展方向。本研究旨在比较三种准直器所能实现的图像质量。

材料与方法

使用SIMIND蒙特卡罗代码模拟程序对配备高能（HE）、中能（ME）和低能高分辨率准直器的西门子医疗系统Symbia进行模拟。针对Lu - 177点源，在三种不同的主能量窗宽度（20%、15%和10%）下采集计数。绘制并分析了主点扩散函数和散射点扩散函数，以及几何、穿透、散射情况。

结果

在Lu - 177成像中，发现20%的主能量窗和ME准直器是最佳的。当不需要分辨率时，可以使用HE准直器。

结论

这些结果为Lu - 177 SPECT成像提供了最佳能量窗和准直器，将有助于Lu - 177的定量分析。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/08b3/6958958/9b2dd1b2921b/IJNM-35-36-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/08b3/6958958/25de57ff9156/IJNM-35-36-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/08b3/6958958/2319600df5d4/IJNM-35-36-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/08b3/6958958/5648b8e9d56f/IJNM-35-36-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/08b3/6958958/f5a55f7ec144/IJNM-35-36-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/08b3/6958958/df3bb878a7ec/IJNM-35-36-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/08b3/6958958/9b2dd1b2921b/IJNM-35-36-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/08b3/6958958/25de57ff9156/IJNM-35-36-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/08b3/6958958/2319600df5d4/IJNM-35-36-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/08b3/6958958/5648b8e9d56f/IJNM-35-36-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/08b3/6958958/f5a55f7ec144/IJNM-35-36-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/08b3/6958958/df3bb878a7ec/IJNM-35-36-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/08b3/6958958/9b2dd1b2921b/IJNM-35-36-g006.jpg

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