Kassinger Stephen J, van Hoek Monique L
George Mason University, School of Systems Biology, George Mason University, 10920 George Mason Circle, Manassas, VA, 20110, USA.
Synth Syst Biotechnol. 2020 Jan 13;5(1):1-10. doi: 10.1016/j.synbio.2020.01.001. eCollection 2020 Mar.
Synthetic biologists are exploiting biofilms as an effective mechanism for producing various outputs. Metabolic optimization has become commonplace as a method of maximizing system output. In addition to production pathways, the biofilm itself contributes to the efficacy of production. The purpose of this review is to highlight opportunities that might be leveraged to further enhance production in preexisting biofilm production systems. These opportunities may be used with previously established production systems as a method of improving system efficiency further. This may be accomplished through the reduction in the cost of establishing and maintaining biofilms, and maintenance of the enhancement of product yield per unit of time, per unit of area, or per unit of required input.
合成生物学家正在利用生物膜作为产生各种产物的有效机制。代谢优化作为一种使系统产出最大化的方法已变得很常见。除了生产途径外，生物膜本身也有助于提高生产效率。本综述的目的是强调那些可被利用以进一步提高现有生物膜生产系统产量的机会。这些机会可与先前建立的生产系统一起使用，作为进一步提高系统效率的一种方法。这可以通过降低建立和维持生物膜的成本，以及维持单位时间、单位面积或单位所需投入的产品产量的提高来实现。
