Bertoncelli Carlo M, Altamura Paola, Vieira Edgar Ramos, Iyengar Sundaraja Sitharama, Solla Federico, Bertoncelli Domenico
Florida International University, USA; Children Hospital E.E.A.P. H. Germain, France.
D'Annunzio University of Chieti-Pescara, Italy.
Health Informatics J. 2020 Sep;26(3):2105-2118. doi: 10.1177/1460458219898568. Epub 2020 Jan 20.
Logistic regression-based predictive models are widely used in the healthcare field but just recently are used to predict comorbidities in children with cerebral palsy. This article presents a logistic regression approach to predict health conditions in children with cerebral palsy and a few examples from recent research. The model named PredictMed was trained, tested, and validated for predicting the development of scoliosis, intellectual disabilities, autistic features, and in the present study, feeding disorders needing gastrostomy. This was a multinational, cross-sectional descriptive study. Data of 130 children (aged 12-18 years) with cerebral palsy were collected between June 2005 and June 2015. The logistic regression-based model uses an algorithm implemented in R programming language. After splitting the patients in training and testing sets, logistic regressions are performed on every possible subset (tuple) of independent variables. The tuple that shows the best predictive performance in terms of accuracy, sensitivity, and specificity is chosen as a set of independent variables in another logistic regression to calculate the probability to develop the specific health condition (e.g. the need for gastrostomy). The average of accuracy, sensitivity, and specificity score was 90%. Our model represents a novelty in the field of some cerebral palsy-related health outcomes treatment, and it should significantly help doctors' decision-making process regarding patient prognosis.
基于逻辑回归的预测模型在医疗保健领域被广泛使用,但直到最近才被用于预测脑瘫患儿的合并症。本文介绍了一种用于预测脑瘫患儿健康状况的逻辑回归方法以及一些近期研究的实例。名为PredictMed的模型经过训练、测试和验证,用于预测脊柱侧弯、智力残疾、自闭症特征的发展情况,在本研究中还用于预测需要胃造口术的喂养障碍。这是一项跨国横断面描述性研究。在2005年6月至2015年6月期间收集了130名年龄在12至18岁之间的脑瘫患儿的数据。基于逻辑回归的模型使用R编程语言实现的算法。在将患者分为训练集和测试集后,对每个可能的自变量子集(元组)进行逻辑回归。在准确性、敏感性和特异性方面表现出最佳预测性能的元组被选作另一逻辑回归中的一组自变量,以计算出现特定健康状况(如需要胃造口术)的概率。准确性、敏感性和特异性评分的平均值为90%。我们的模型在一些与脑瘫相关的健康结局治疗领域具有创新性,它应能显著帮助医生进行有关患者预后的决策过程。