Emerg Infect Dis. 2020 Feb;26(2):220-228. doi: 10.3201/eid2602.181732.
We conducted a retrospective cohort study to assess the effect of influenza virus type and subtype on disease severity among hospitalized influenza patients in Spain. We analyzed the cases of 8,985 laboratory-confirmed case-patients hospitalized for severe influenza by using data from a national surveillance system for the period 2010-2017. Hospitalized patients with influenza A(H1N1)pdm09 virus were significantly younger, more frequently had class III obesity, and had a higher risk for pneumonia or acute respiratory distress syndrome than patients infected with influenza A(H3N2) or B (p<0.05). Hospitalized patients with influenza A(H1N1)pdm09 also had a higher risk for intensive care unit admission, death, or both than patients with influenza A(H3N2) or B, independent of other factors. Determining the patterns of influenza-associated severity and how they might differ by virus type and subtype can help guide planning and implementation of adequate control and preventive measures during influenza epidemics.
我们开展了一项回顾性队列研究，以评估西班牙住院流感患者中流感病毒类型和亚型对疾病严重程度的影响。我们利用 2010-2017 年期间全国流感监测系统的数据，分析了 8985 例经实验室确诊的因重症流感住院的病例患者。与感染甲型 H3N2 或乙型流感的患者相比，感染甲型 H1N1(pdm09)病毒的住院患者年龄更小，更常患有 III 级肥胖症，且发生肺炎或急性呼吸窘迫综合征的风险更高（<0.05）。甲型 H1N1(pdm09)感染的住院患者发生重症监护病房入住、死亡或两者兼有的风险也高于甲型 H3N2 或乙型流感患者，且独立于其他因素。确定与流感相关的严重程度模式及其可能因病毒类型和亚型而异的方式，可以帮助指导流感大流行期间充分控制和预防措施的规划和实施。
