Department of Biomedicine, University of Bergen, Jonas Lies vei 91, N-5020 Bergen, Norway; Department of Biological Sciences, University of Bergen, Thormøhlensgate 53 A, N-5020 Bergen, Norway; Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, 160 College Street, Toronto, ON M5S 3E1, Canada.
Department of Biochemistry, UGent Center for Medical Biotechnology, Ghent University, Albert Baertsoenkaai 3, 9000 Gent, Belgium.
Trends Biochem Sci. 2019 Jun;44(6):502-516. doi: 10.1016/j.tibs.2018.11.010. Epub 2019 Jan 2.
Actin is one of the most abundant proteins in eukaryotic cells and the main component of the microfilament system. It plays essential roles in numerous cellular activities, including muscle contraction, maintenance of cell integrity, and motility, as well as transcriptional regulation. Besides interacting with various actin-binding proteins (ABPs), proper actin function is regulated by post-translational modifications (PTMs), such as acetylation, arginylation, oxidation, and others. Here, we explain how actin PTMs can contribute to filament formation and stability, and may have additional actin regulatory functions, which potentially contribute to disease development.
肌动蛋白是真核细胞中最丰富的蛋白质之一，也是微丝系统的主要组成部分。它在许多细胞活动中发挥着重要作用，包括肌肉收缩、维持细胞完整性和运动，以及转录调控。除了与各种肌动蛋白结合蛋白（ABP）相互作用外，肌动蛋白的正常功能还受到翻译后修饰（PTM）的调节，如乙酰化、精氨酸化、氧化等。在这里，我们解释了肌动蛋白 PTM 如何有助于纤维丝的形成和稳定性，以及可能具有额外的肌动蛋白调节功能，这可能有助于疾病的发展。
