意大利北部系统性红斑狼疮患者的HLA - DR抗原和抗心磷脂抗体
HLA-DR antigens and anticardiolipin antibodies in northern Italian systemic lupus erythematosus patients.
作者信息
Savi M, Ferraccioli G F, Neri T M, Zanelli P, Dall'Aglio P P, Tincani A, Balestrieri G, Carella G, Cattaneo R
机构信息
Clinical Medicine and Nephrology Department, University of Parma, Italy.
出版信息
Arthritis Rheum. 1988 Dec;31(12):1568-70. doi: 10.1002/art.1780311216.
Eighty systemic lupus erythematosus (SLE) patients attending 3 clinical centers were evaluated immunologically and immunogenetically. No HLA class II antigens were found to be significantly associated with SLE in these patients. A highly significant (P = 6.17 x 10(-7) association was observed between anticardiolipin antibodies and DR7. A lesser association (P less than 0.025) was also observed between DR2 and/or DR3 and anti-Ro (SS-A) antibodies. No relationship was found between any DR antigen and anti-Sm/RNP, anti-double-stranded DNA, or anti-La (SS-B) antibodies.
对来自3个临床中心的80例系统性红斑狼疮（SLE）患者进行了免疫学和免疫遗传学评估。在这些患者中，未发现HLA II类抗原与SLE有显著相关性。观察到抗心磷脂抗体与DR7之间存在高度显著的相关性（P = 6.17×10⁻⁷）。DR2和/或DR3与抗Ro（SS - A）抗体之间也观察到较弱的相关性（P＜0.025）。未发现任何DR抗原与抗Sm/RNP、抗双链DNA或抗La（SS - B）抗体之间存在关联。
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