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进化、史前史与维生素 D。

Evolution, Prehistory and Vitamin D.

机构信息

Department of Dermatology, Middlemore Hospital, Auckland 2025, New Zealand.

Department of Medicine, The University of Auckland, Auckland 1023, New Zealand.

出版信息

Int J Environ Res Public Health. 2020 Jan 19;17(2):646. doi: 10.3390/ijerph17020646.

Abstract

Aspects of human evolutionary biology and prehistory are discussed in relation to vitamin D. The evolution of hairlessness, combined with the need for efficient eccrine sweat production for cooling, provided evolutionary pressure to protect the skin from ultraviolet damage by developing cutaneous pigmentation. There was a subsequent loss of pigmentation as humans journeyed to northern latitudes. Their increasing mastery of technology outstripped evolution's finite pace as further dispersal occurred around the globe. A timeline for the development of clothing to provide warmth, and the consequent shielding from ultraviolet light, which diminished vitamin D synthesis, can be inferred by an examination of mutations in the human louse.

摘要

本文讨论了人类进化生物学和史前史与维生素 D 的关系。人类的无毛进化,加上对高效外分泌汗液产生的散热需求,为了保护皮肤免受紫外线伤害,产生了皮肤色素沉着,从而产生了进化压力。随着人类向北方迁徙,色素沉着随后减少。随着人类在全球范围内进一步扩散,他们对技术的掌握超过了进化的有限速度。通过检查人体虱子的突变,可以推断出发展提供温暖的衣服以及随之而来的免受紫外线照射的保护,这会减少维生素 D 的合成。

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本文引用的文献

1
The Evolutionary History of Human Skin Pigmentation.人类皮肤色素沉着的进化史。
J Mol Evol. 2020 Jan;88(1):77-87. doi: 10.1007/s00239-019-09902-7. Epub 2019 Jul 30.
2
Early hominids may have been weed species.早期人类可能是杂草物种。
Proc Natl Acad Sci U S A. 2018 Feb 6;115(6):1244-1249. doi: 10.1073/pnas.1719669115. Epub 2018 Jan 22.
5
Vitamin D-Binding Protein Concentrations Quantified by Mass Spectrometry.通过质谱法定量的维生素D结合蛋白浓度
N Engl J Med. 2015 Oct 8;373(15):1480-2. doi: 10.1056/NEJMc1502602. Epub 2015 Sep 23.

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