2010 - 2016年中国肉鸡供应链及患者中耐环丙沙星的肯塔基血清型ST198菌株
Ciprofloxacin-Resistant Serovar Kentucky ST198 in Broiler Chicken Supply Chain and Patients, China, 2010-2016.
作者信息
Xiong Zhiying, Wang Shaojun, Huang Yumei, Gao Yuan, Shen Haiyan, Chen Zhengquan, Bai Jie, Zhan Zeqiang, Wen Junping, Liao Ming, Zhang Jianmin
机构信息
National and Regional Joint Engineering Laboratory for Medicament of Zoonoses Prevention and Control, Lingnan Guangdong Laboratory of Modern Agriculture, College of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, China.
Institude of Animal Health, Guangdong Academy of Agricultural Sciences, Guangzhou 510640, China.
出版信息
Microorganisms. 2020 Jan 19;8(1):140. doi: 10.3390/microorganisms8010140.
serovar Kentucky (. Kentucky) sequence type 198 has emerged as a global zoonotic pathogen. We explored serovar Kentucky ST198 samples from the broiler chicken supply chain and patients between 2010 and 2016. Here, we collected 180 . Kentucky isolates from clinical cases and the poultry supply chain. We performed pulsed-field gel electrophoresis and multilocus sequence typing. We assessed mutations in the quinolone resistance-determining regions and screened for the presence of the genomic island 1 (SGI1). We determined that 63 (35.0%) of the 180 isolates were . Kentucky ST198. Chinese strains of . Kentucky ST198 have a high transmission of ciprofloxacin resistance (38/63, 60.3%) and a high risk of multidrug resistance. The quinolone resistance of the . Kentucky ST198 strain found in China may be due to mutations in its quinolone resistance-determining region. Our study firstly revealed that ciprofloxacin-resistant . Kentucky ST198 strains can undergo cross-host transmission, thereby causing a serious foodborne public health problem in China.
肯塔基血清型（. Kentucky）序列型198已成为一种全球人畜共患病原体。我们对2010年至2016年间来自肉鸡供应链和患者的肯塔基血清型ST198样本进行了研究。在此，我们从临床病例和家禽供应链中收集了180株. Kentucky分离株。我们进行了脉冲场凝胶电泳和多位点序列分型。我们评估了喹诺酮耐药决定区的突变，并筛查了基因组岛1（SGI1）的存在情况。我们确定180株分离株中有63株（35.0%）为. Kentucky ST198。中国的. Kentucky ST198菌株对环丙沙星耐药的传播率很高（38/63，60.3%），且多重耐药风险高。在中国发现的. Kentucky ST198菌株的喹诺酮耐药性可能归因于其喹诺酮耐药决定区的突变。我们的研究首次揭示，耐环丙沙星的. Kentucky ST198菌株可发生跨宿主传播，从而在中国引发严重的食源性公共卫生问题。
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