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新的免疫治疗反应预测因子使我们更深入地了解肿瘤微环境。

New predictors for immunotherapy responses sharpen our view of the tumour microenvironment.

出版信息

Nature. 2020 Jan;577(7791):474-476. doi: 10.1038/d41586-019-03943-0.

DOI:10.1038/d41586-019-03943-0
PMID:31965091
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7523515/
Abstract

Three studies reveal that the presence in tumours of two key immune components — B cells and tertiary lymphoid structures — is associated with favourable outcomes when individuals undergo immunotherapy.

摘要

三项研究表明，当个体接受免疫疗法时，肿瘤中存在两种关键免疫成分——B 细胞和三级淋巴结构——与有利的结果相关。

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Nature. 2020 Jan;577(7791):556-560. doi: 10.1038/s41586-019-1906-8. Epub 2020 Jan 15.
2
B cells and tertiary lymphoid structures promote immunotherapy response.B 细胞和三级淋巴结构促进免疫治疗反应。
Nature. 2020 Jan;577(7791):549-555. doi: 10.1038/s41586-019-1922-8. Epub 2020 Jan 15.
3
Tertiary lymphoid structures improve immunotherapy and survival in melanoma.三级淋巴结构可改善黑色素瘤的免疫治疗和生存率。
既往的失败与新的视野：高级别浆液性卵巢癌中三级淋巴结构的细微差别可能有助于免疫治疗的有效性。
J Immunother Cancer. 2025 Apr 17;13(4):e011670. doi: 10.1136/jitc-2025-011670.
4
Exploring effects of gut microbiota on tertiary lymphoid structure formation for tumor immunotherapy.探索肠道微生物群对肿瘤免疫治疗中三级淋巴结构形成的影响。
Front Immunol. 2025 Mar 7;15:1518779. doi: 10.3389/fimmu.2024.1518779. eCollection 2024.
5
Photodynamic priming with red light triggers adaptive immune responses in a pancreatic cancer mouse model.在胰腺癌小鼠模型中，红光光动力预激发可触发适应性免疫反应。
J Photochem Photobiol B. 2025 Apr;265:113126. doi: 10.1016/j.jphotobiol.2025.113126. Epub 2025 Feb 19.
6
Construction of hot tumor classification models in gastrointestinal cancers.胃肠道癌中热肿瘤分类模型的构建
J Transl Med. 2025 Feb 21;23(1):218. doi: 10.1186/s12967-025-06230-x.
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Differential antibody response to EBV proteome following EBVST immunotherapy in EBV-associated lymphomas.EBV相关淋巴瘤患者接受EBVST免疫治疗后对EBV蛋白质组的差异性抗体反应。
Blood Adv. 2025 Apr 8;9(7):1658-1669. doi: 10.1182/bloodadvances.2024014937.
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