雄性兔饮食诱导性高脂血症期间血细胞成分血管内行为的活体显微镜观察。
Intravital-microscopic observations on the intravascular behavior of blood cell components during dietary-induced hyperlipidemia in the male rabbit.
作者信息
Asano M, Ohkubo C, Hirokawa A, Sasaki A, Tochihara Y, Chiba Y
机构信息
Department of Physiological Hygiene, Institute of Public Health, Tokyo, Japan.
出版信息
Biorheology. 1988;25(1-2):329-38. doi: 10.3233/bir-1988-251-242.
PMID:3196830
Abstract
In normal male rabbits loaded dietary cholesterol, intravital-microscopy revealed a marked acceleration of intravascular adhesiveness of white blood cells and aggregability of red blood cells and a swarming of lipid-laden macrophages in connective tissue space concurrently with a systemic hyperlipidemia and anemia. Possible roles of the microcirculatory changes in the atherogenesis were discussed.
摘要
在摄入膳食胆固醇的正常雄性兔子中，活体显微镜检查显示，在出现系统性高脂血症和贫血的同时，白细胞的血管内黏附性显著加快，红细胞的聚集性增加，结缔组织间隙中出现大量载脂巨噬细胞。讨论了微循环变化在动脉粥样硬化形成中的可能作用。
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