Patel S N, Rose S P, Stewart M G
Open University, Biology Department, Milton Keynes, U.K.
Brain Res. 1988 Oct 25;463(1):168-73. doi: 10.1016/0006-8993(88)90542-2.
The density of dendritic spines on large, multipolar, projection neurons in the intermediate medial hyperstriatum ventrale (IMHV) of 1-day-old chicks was examined after training on a one-trial passive avoidance task. Chicks trained on the task were given a brief, subconvulsive transcranial electroshock 5 min after training, a procedure which rendered about half of them amnesic. The spine density was found to be significantly higher 24-26 h after training in the left IMHV in chicks that remembered the response compared to chicks rendered amnesic. These data, taken together with our earlier observations on spine density changes following training, argue strongly in favour of a specific role for dendritic spines in memory formation in the chick.
在对1日龄雏鸡进行单次被动回避任务训练后，检测了其内侧中间层腹侧（IMHV）中大型多极投射神经元上树突棘的密度。接受该任务训练的雏鸡在训练后5分钟接受一次短暂的、亚惊厥性的经颅电击，该操作使约一半雏鸡失忆。结果发现，与失忆雏鸡相比，记住反应的雏鸡在训练后24 - 26小时，左侧IMHV中的树突棘密度显著更高。这些数据，结合我们早期对训练后树突棘密度变化的观察结果，有力地支持了树突棘在雏鸡记忆形成中具有特定作用的观点。
