School of Medicine, Deakin University, Geelong, Australia.
Department for Management of Science and Technology Development, Ton Duc Thang University, Ho Chi Minh City, Vietnam.
Curr Pharm Des. 2020;26(6):701-709. doi: 10.2174/1381612826666200122124621.
Improving drug bioavailability in the pharmaceutical field is a challenge that has attracted substantial interest worldwide. The controlled release of a drug can be achieved with a variety of strategies and novel materials in the field. In addition to the vast development of innovative materials for improving therapeutic effects and reducing side effects, the exploration of remarkable existing materials could encourage the discovery of diverse approaches for adapted drug delivery systems. Recently, superdisintegrants have been proposed for drug delivery systems as alternative approaches to maximize the efficiency of therapy. Although superdisintegrants are well known and used in solid dosage forms, studies on strategies for the development of drug delivery systems using superdisintegrants are lacking. Therefore, this study reviews the use of superdisintegrants in controlled drug release dosage formulations. This overview of superdisintegrants covers developed strategies, types (including synthetic and natural materials), dosage forms and techniques and will help to improve drug delivery systems.
提高药物在制药领域的生物利用度是一个全球性的挑战，引起了广泛关注。可以通过多种策略和新型材料来实现药物的控制释放。除了为提高治疗效果和减少副作用而开发大量创新材料外，探索显著的现有材料还可以鼓励发现用于适应药物传递系统的不同方法。最近，超崩解剂已被提议用于药物传递系统，作为提高治疗效率的替代方法。尽管超崩解剂在固体制剂中已被广泛认识和使用，但关于使用超崩解剂开发药物传递系统的策略的研究还很缺乏。因此，本研究综述了超崩解剂在控制药物释放剂型中的应用。本综述涵盖了超崩解剂的开发策略、类型（包括合成和天然材料）、剂型和技术，将有助于改善药物传递系统。
