Friess W
University of Erlangen, Germany.
Eur J Pharm Biopharm. 1998 Mar;45(2):113-36. doi: 10.1016/s0939-6411(98)00017-4.
The use of collagen as a biomaterial is currently undergoing a renaissance in the tissue engineering field. The biotechnological applications focus on the aspects of cellular growth or delivery of proteins capable of stimulating cellular response. However, basic knowledge about collagen biochemistry and the processing technology in combination with understanding of the physico-chemical properties is necessary for an adequate application of collagen for carrier systems. The purpose of this review article is to summarize information available on collagen dosage forms for drug delivery as well as to impart an overview of the chemical structures and the galenical properties including detailed description of the processing steps - extraction, purification, chemical crosslinking and sterilization. The most successful and stimulating applications are shields in ophthalmology, injectable dispersions for local tumor treatment, sponges carrying antibiotics and minipellets loaded with protein drugs. However, the scientific information about manipulating release properties or mechanistic studies is not as abundant as for some synthetic polymers.
目前，胶原蛋白作为一种生物材料在组织工程领域正经历复兴。生物技术应用主要集中在细胞生长或能够刺激细胞反应的蛋白质递送方面。然而，要将胶原蛋白充分应用于载体系统，需要具备胶原蛋白生物化学、加工技术等基础知识，并了解其物理化学性质。这篇综述文章的目的是总结有关用于药物递送的胶原蛋白剂型的现有信息，并概述其化学结构和药剂学性质，包括对加工步骤——提取、纯化、化学交联和灭菌的详细描述。最成功且令人振奋的应用包括眼科用屏障、用于局部肿瘤治疗的可注射分散体、载有抗生素的海绵以及装载蛋白质药物的微丸。然而，与一些合成聚合物相比，关于调控胶原蛋白释放特性或进行机理研究的科学信息并不丰富。
