Häkkinen I, Paasivuo R, Partanen P
Department of Pathology, University of Turku, Finland.
Gut. 1988 Sep;29(9):1194-7. doi: 10.1136/gut.29.9.1194.
A recently developed double test for detecting faecal occult blood (a sensitive guaiac test combined with a quantitative immunological human haemoglobin test), was adapted to population screening. The study involved an unselected population of 10,343, aged 49-74 years. There was 66.5% participation. 174 colonoscopies were done, yielding seven adenocarcinomas, 44 adenomas and four hyperplastic polyps. By eliminating benign anal tract bleeding, the number of endoscopies decreased from 340 to 174. Most tumours showed an absorbance over 0.80, and it is suggested that by setting the lower limit of positivity at the 0.80 absorbance level, the number of clinical examinations could fall to about 1%, without substantially missing tumours.
一种最近开发的用于检测粪便潜血的双重检测方法（一种灵敏的愈创木脂检测法与定量免疫人血红蛋白检测法相结合）被应用于人群筛查。该研究涉及10343名年龄在49至74岁之间的未经过筛选的人群。参与率为66.5%。进行了174例结肠镜检查，发现7例腺癌、44例腺瘤和4例增生性息肉。通过消除良性肛管出血，内镜检查的数量从340例减少到174例。大多数肿瘤的吸光度超过0.80，有人建议将阳性下限设定在0.80吸光度水平，这样临床检查的数量可能会降至约1%，而不会大量漏诊肿瘤。
