Tianjin Key Laboratory of Oral and Maxillofacial Function Reconstruction, Tianjin Stomatological Hospital, The Affiliated Stomatological Hospital of Nankai University, Tianjin, 300041, China.
State Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Bioactive Materials, Ministry of Education, and, College of Life Sciences, Nankai University, Tianjin, 300071, China.
Angew Chem Int Ed Engl. 2020 Jun 15;59(25):10008-10012. doi: 10.1002/anie.201916430. Epub 2020 Feb 25.
Host-guest complexation between calix[5]arene and aggregation-induced emission luminogen (AIEgen) can significantly turn off both the energy dissipation pathways of intersystem crossing and thermal deactivation, enabling the absorbed excitation energy to mostly focus on fluorescence emission. The co-assembly of calix[5]arene amphiphiles and AIEgens affords highly emissive supramolecular AIE nanodots thanks to their interaction severely restricting the intramolecular motion of AIEgens, which also show negligible generation of cytotoxic reactive oxygen species. In vivo studies with a peritoneal carcinomatosis-bearing mouse model indicate that such supramolecular AIE dots have rather low in vivo side toxicity and can serve as a superior fluorescent bioprobe for ultrasensitive fluorescence image-guided cancer surgery.
主体-客体络合作用发生在杯[5]芳烃和聚集诱导发光（AIEgen）之间，这可以显著关闭系间窜越和热失活这两种能量耗散途径，使吸收的激发能主要集中在荧光发射上。由于杯[5]芳烃两亲物和 AIEgen 的共组装严重限制了 AIEgen 的分子内运动，使它们相互作用，从而提供了高度发光的超分子 AIE 纳米点，同时也表现出细胞毒性活性氧的产生可忽略不计。在伴有腹膜癌转移的小鼠模型的体内研究表明，这种超分子 AIE 点具有较低的体内副作用，可用作超灵敏荧光图像引导癌症手术的优异荧光生物探针。
